| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Inhibition of metastatic skin cancer using nano-micelle generating microneedles containing doxorubicin |
| 초록 |
Microneedle (MN) has been considered as a promising device which allow transcutaneous injection of diverse drugs with painlessly and easily. In this study, nano-micelle generating dissolving MN was prepared by a biocompatible amphiphilic tri-block copolymer. When formulate with doxorubicin (DOX) in the MN, the hydrophobic anticancer drug can be dissolved in an aqueous medium by entrapped in nano-micelles generated by dissolution of the MN. The transdermal application of the DOX-incorporated MN can significantly inhibit the growth of melanoma in a mouse skin cancer model. In addition, owing to its small size (＜ 50 nm), the nano-micelle can efficiently migrate to the sentinel lymph nodes, killing the metastatic melanoma cells. Therefore, the use of locally administration of MN can be considered as a potential therapeutic tool for the inhibition of metastatic melanoma. |
| 저자 |
임수연, 김이슬, 김다훤, 정재백, 조희주, 김동민, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Microneedle; doxorubicin; metastasis cancer
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| E-Mail |
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