| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Manganese oxide structure and surface modification effect on T1 relaxivity |
| 초록 |
Hollow manganese oxide nanocubes were produced and modified by either ligand exchange or ligand encapsulation, rendering them water soluble. Phthalic acid buffer induced the formation of hollow nanosphere morphologies.1 These as-synthesized nanocubes were further compared proving that increase in the nanoparticle surface percentage allows for more water accessibility leading to higher r1. Exchanging the ligand along with hollowing out the structure tremendously increases the surface-area-to-volume ratio leading to the increased accessibility of water protons to the exposed metal ions. MR imaging studies revealed that the hollow ligand exchange particles exhibit significantly enhanced longitudinal relaxation by allowing direct contact with water protons. The nanoparticles were subsequently functionalized with a targeting monoclonal antibody to selectively target cancer cells. Further in vivo MR studies revealed the particles to be effective T1 MR contrast agents. |
| 저자 |
강병훈1, 한승민1, 신무광1, 기지선1, 손혜영2, 허용민1, 함승주1
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| 소속 |
1연세대, 2연세의료원 |
| 키워드 |
manganese oxide; T1 relaxivity; modification
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| E-Mail |
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