| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Bioactivatable Poly(ethylene glycol)-Doxorubicin Conjugate for Cancer Therapy |
| 초록 |
In this study, we synthesized a bioreducible methoxy poly(ethylene glycol)-doxorubicin (mPEG-ss-DOX) conjugate for targeted cancer therapy. Anticancer agent DOX was chemically conjugated with mPEG via a bioreducible disulfide bond. The amphiphilic mPEG-ss-DOX self-assembled in aqueous media to form nanoparticles (NPs) and efficiently encapsulated superparamagnetic iron oxide nanoparticles (SPIONs) to form the SPION-loaded NPs. The SPION-loaded NPs showed a narrow size distribution with an average size of about 80 nm and demonstrated a good colloidal stability. The bioreducible dissociation and drug release properties of the NPs were observed in the presence of dithiothreitol (DTT). The iron oxide could be encapsulated up to ~60 wt% proportionally to the feed ratio. The SPION-loaded NPs showed not only lower toxicity than free DOX, also the tumor targeting and imaging potential. The resulting SPION-loaded NPs could be useful for cancer MR imaging and chemotherapy. |
| 저자 |
김유경1, 허강무2
|
| 소속 |
1충남대, 2충남대하교 |
| 키워드 |
Bioreducible polymer; Magnetic nanoparticle
|
| E-Mail |
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