Rheological characterization of novel physically crosslinked terpolymeric hydrogels at different temperatures

Muhammad Aslam Malana; Rubab Zohra; Muhammad Saleem Khan

Korea-Australia Rheology Journal, Vol.24, No.3, 155-162, September, 2012

DOI10.1007/s13367-012-0019-9 Export Citation

Rheological characterization of novel physically crosslinked terpolymeric hydrogels at different temperatures

Muhammad Aslam Malana, Rubab Zohra^†, and Muhammad Saleem Khan¹

Chemistry Department, Bahauddin Zakarya University, Multan, Pakistan
¹Centre of Excellence in Physical Chemistry, University of Peshawer, Pakistan

E-mail:

The main objective of this research work is to reveal the detailed and extensive rheological characterization of terpolymeric hydrogel formulations using a variety of monomers having different concentrations of acrylic acid and applying a range of temperatures. The hydrogels with the different concentrations of acrylic acid were prepared in the absence of air using three different monomers, by free radical polymerization, gradually increasing the temperature up to polymerization point, using ethyl alcohol as solvent. Different shear measurements were performed to study rheological properties, temperature dependence, and yield strength of acrylic acid pharmaceutical hydrogels. Various models were applied to analyze the rheological behavior of the gels. The acrylic acid pharmaceutical gels having physical cross links in the gel networks, exhibit remarkable temperature dependence especially with relatively higher concentration of acrylic acid at greater shear rate. Flow curves plotted at various temperatures indicate that these gels exhibit a reasonable pseudoplastic behavior. All these hydrogels require appropriate yield strength to break their network structures. The gel samples exhibit the best fit to the Modified Bingham model, which can explain the overall flow behavior of these topical gels. The rheological analysis indicates that these gels may be used as topical gels for targeted and controlled drug delivery at a specific site.

Keywords:rheological;terpolymeric;hydrogels;modified Bingham model

[References]

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Hennik WE, van Nostrum CF, Adv. Drug Deliver., 54, 13 (2002)
Islam MT, Hornido NR, Ciotti S, Ackermann C, Pharm. Research., 21, 1192 (2004)
Jeong B, Kim SW, Bae YH, Adv. Drug Deliver., 54, 37 (2002)
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Nguyen QD, Boger DV, J. Rheol., 27, 321 (1983)
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Owen DH, Peters JJ, Katz DF, Contraception., 64, 393 (2001)
Ramirez A, Fresno MJ, Jimenenz MM, Selles E, Pharmazei., 54, 444 (1999)
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Vyavahare N, Kohn J, J. Polym. Sci. A: Polym. Chem., 32(7), 1271 (1994)
Yahia A, Khayat KH, Cement Concrete Research., 31, 731 (2001)
Zafar ZI, Malana MA, Pervez H, Shad MA, Momina K, Polym.(Korea)., 32, 1 (2008)

[Referenced By]

[1] Alina O, Christina DP, Mihaela VG, Laidia MP, Lucian I, Roman, Biotech. Lett., 16, 47 (2011)

[2] Attapatu DD, Chhabara RP, UhCherr DHT, J, Non-Newtonian Fluid. Mech., 38, 31 (1990)

[3] Barners HA, Appl.Rheol., 9, 262 (1999)

[4] Bird RB, Armstrong RC, Hassager O, Dynamics of polymer liquids, 2nd Ed. Wiley, New York (1987)

[5] Boss GW, Jacobs JJL, van Tomme SR, Veldhuis TFJ, van Nostrum CF, Otter WD, Hennik EE, Eur. J. Phar. Sci., 21, 561 (2004)

[6] Chang JY, Oh YK, Choi HG, Kim YB, Kim CK, Int. J. Pharm., 241, 155 (2002)

[7] Chatterjee S, Bohidar HB, J. Surface Sci.Technol., 22, 1 (2006)

[8] Chen TH, Embree HD, Brown EM, Taylor MM, Payne GF, Biomaterials., 24, 2831 (2003)

[9] Dodov MG, Kumbaradzi EF, Goracinova K, Calis S, Simonoska M, Hincal AA, Acta. Pharm., 53, 241 (2003)

[10] Drury JL, Mooney DJ, Biomaterials., 24, 4337 (2003)

[11] Fergusen J, Kemblowski Z, Applied fluid rheology, Elsevier Applied Science, London and New York (1992)

[12] Guan L, Xu H, Huang D, Polym.(Korea), 34(4), 386 (2010)

[13] Hatefi A, Amsden B, J. Control. Release., 80, 9 (2002)

[14] Hennik WE, van Nostrum CF, Adv. Drug Deliver., 54, 13 (2002)

[15] Islam MT, Hornido NR, Ciotti S, Ackermann C, Pharm. Research., 21, 1192 (2004)

[16] Jeong B, Kim SW, Bae YH, Adv. Drug Deliver., 54, 37 (2002)

[17] Keiweg SL, Geonnotti AR, Katz DF, J. Pharm. Sci., 93, 2941 (2004)

[18] Khutoryanskiy VV, Dubolazov AV, Nurkeeva ZS, Mun GA, Langmuir, 20(9), 3785 (2004)

[19] Kim JY, Song JY, Lee EJ, Park SK, Colloid Polym. Sci., 281, 614 (2003)

[20] Larson RJ, The structure and rheology of complex fluids, oxford University Press, New York (1999)

[21] Levy MC, Andry MC, J. Microencapsule., 8, 335 (1991)

[22] Li SM, Vert M, Macromolecules, 36(21), 8008 (2003)

[23] Nae HN, Reichert WW, Rheol. Acta., 31, 351 (1992)

[24] Nguyen QD, Boger DV, J. Rheol., 27, 321 (1983)

[25] Okay O, Gurun C, J. Appl. Polym. Sci., 46, 401 (1992)

[26] Owen DH, Peters JJ, Katz DF, Contraception., 64, 393 (2001)

[27] Ramirez A, Fresno MJ, Jimenenz MM, Selles E, Pharmazei., 54, 444 (1999)

[28] Rudraraju VS, Wyandt CM, Int. J. Pharm., 292, 63 (2005)

[29] Tamburic S, Craig DQM, Pharm. Res., 13, 279 (1996)

[30] Thor Geirs Dottier TO, Kjoniksen AL, Knudsen KD, Kristmunds Dottier T, Nystrom B, Europ. J. Pharm. Biopharm., 59, 333 (2005)

[31] Tomme SRV, Steenbergen MJV, Smedth SCD, Nostrum CFV, Hennik WE, Biomaterials., 26, 2129 (2005)

[32] Vyavahare N, Kohn J, J. Polym. Sci. A: Polym. Chem., 32(7), 1271 (1994)

[33] Yahia A, Khayat KH, Cement Concrete Research., 31, 731 (2001)

[34] Zafar ZI, Malana MA, Pervez H, Shad MA, Momina K, Polym.(Korea)., 32, 1 (2008)