화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.37, No.3, 387-392, May, 2013
Export Citation
경피전달을 위한 커큐민 젤의 창상치유효과
Wound Healing Effect of Curcumin Gel for Transdermal Delivery
김진, 김만종, 이기영1, †
  • 전남대학교 신화학소재공학과
  • 1전남대학교 응용화학공학부 & 촉매연구소
Jin Kim, Man Jong Kim, and Ki-Young Lee1, †
  • Department of Advanced Chemicals and Engineering, Chonnam National University, Gwangju 500-757, Korea
  • 1Faculty of Applied Chemical Engineering & The Research Institute for Catalysis, Chonnam National University, Gwangju 500-757, Korea
E-mail:
초록
이 연구의 목적은 curcumin 함유 젤을 쥐의 손상된 등부위 조직에 적용하여 경피전달에 따른 창상치유 효과를 관찰하였다. 카보머 934와 프로필렌글리콜을 이용하여 curcumin 함량이 1%인 젤을 제조하였다. Curcumin 자체의 항산화능과 함유 젤의 세포독성, 항염증의 효과를 평가하였다. 1,1-Diphenyl-2-picryl hydrazyl(DPPH)로 관찰한 자유라디칼 소거능은 12.5 ppm 농도에서 50% 저해능을 관찰하였다. Curcumin 젤은 RAW 264.7 세포에서 lipopolysaccharide(LPS)로 유도한 nitric oxide(NO) 생성이 억제되는 것을 확인했다. In vivo 동물실험에서 curcumin 젤의 처치그룹이 curcumin이 함유되지 않은 젤과 비교했을 때 창상 부위의 재 상피화의 경향이 확연히 증가된 것을 실험기간 동안 관찰할 수 있었다. 이 연구는 결과적으로 curcumin 젤은 상처치료의 증진을 도와주는 것을 알 수 있었다.
The aim of this study was to investigate the effect of trasdermal delivery of the curcumin gel on healing of the rats’ dorsum wounds. Carbopol 934 and propylene glycol were used to prepare gels containing 1% curcumin. Curcumin gel was evaluated for various properties such as antioxidant, cell viability, anti-inflammatory, in vivo wound healing. The free radical scavenging activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) was 50% at 12.5 ppm concentration. Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells by curcumin gel. In the curcumin gel-treated group, the re-epithelialization in wounds was significantly increased compared to the control group throughout the experimental period. These results suggested that curcumin may be helpful for the promotion of wound healing.
Keywords:curcumin;cosmeceuticals;transdermal delivery;re-epithelialization.
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