Preparation and stability of fucoxanthin-loaded microemulsions

Jing Dai; Sang Moo Kim; Il-Shik Shin; Jong Dai Kim; Hyeon Yong Lee; Won Cheol Shin; Jin-Chul Kim

Journal of Industrial and Engineering Chemistry, Vol.20, No.4, 2103-2110, July, 2014

DOI10.1016/j.jiec.2013.09.039 Export Citation

Preparation and stability of fucoxanthin-loaded microemulsions

Jing Dai, Sang Moo Kim¹, Il-Shik Shin¹, Jong Dai Kim², Hyeon Yong Lee³, Won Cheol Shin⁴, and Jin-Chul Kim^†

College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chuncheon, Kangwon-do, 200-701, Republic of Korea
¹Department of Marine Food Science and Technology, Gangneung-Wonju National University, Gangneung, Kangwon-do, 210-702, Republic of Korea
²Department of Food Science and Biotechnology, Kangwon National University, Chuncheon, Kangwon-do, 200-701, Republic of Korea
³Department of Food Science and Engineering, Seowon University, Cheongju, Chungbuk, 361-742, Republic of Korea
⁴Department of Bioengineering and Technology, Kangwon National University, Chuncheon, Kangwon-do, 200-701, Republic of Korea

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Oil-in-water microemulsions (MEs) containing fucoxanthin were prepared. The stability of MEs stored at 4 ℃ was investigated for 4 weeks in terms of droplet size change and phase separation. The ME having the oil content of 2% was stable throughout the experiment. As the oil content increased to 3% and 4%, the sizes increased with time for the last 3 weeks. Further increase to 5% led to the phase separation at the 4th week. About 95% of fucoxanthin was maintained for 4 weeks once no phase separation took place soon after the preparation.

Keywords:Oil-in-water microemulsions;Fucoxanthin;Surfactant;Tween 80;Stability

[References]

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Lawrence MJ, Rees GD, Adv. Drug. Delivery Rev., 45, 89 (2000)
Guyot A, Tauer K, Adv. Polym. Sci., 111, 43 (1994)
Farago B, Richter D, Huang JS, Safran SA, Milner ST, Phys. Rev. Lett., 65, 3348 (1990)
Sagitani H, Friberg S, J. Dispersion Sci. Technol., 1, 151 (1980)
Attwood D, Mallon C, Taylor CJ, Int. J. Pharm., 84, R5 (1992)
Aboofazeli R, Lawrence CB, Wicks SR, Lawrence MJ, Int. J. Pharm., 111, 63 (1994)
Dora CL, Silva LFC, Putaux JL, Nishiyama Y, Pignot-Paintrand I, Borsali R, Lemos-Senna E, J. Nanosci. Nanotechnol., 8, 202 (2012)
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Chang LC, Wu CL, Liu CW, Chou WH, Li PC, Tsai TR, J. Biomed. Nanotechnol., 7, 558 (2011)
Jordan M, Nayel A, Brownlow B, Elbayoumi T, J. Biomed. Nanotechnol., 8, 944 (2012)
Lococo D, Mora-Huertas CE, Fessi H, Zaanoun I, Elaissari A, J. Biomed. Nanotechnol., 8, 843 (2012)
Lee KC, Maturo C, Rodriguez R, Nguyen HL, Shorr R, J. Nanosci. Nanotechnol., 11, 6642 (2011)
Bagwe RP, Kanicky JR, Palla BJ, Patanjali PK, Shah DO, Crit. Rev. Ther. Drug Carr. Syst., 18, 77 (2001)
Delgado-Vargas F, Jimenez AR, Paredes-Lopez O, Crit. Rev. Food Sci. Nutr., 40, 173 (2000)
Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K, Biochem. Biophys. Res. Commun., 332(2), 392 (2005)
Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita K, Asia Pac. J. Clin. Nutr., 17, 196 (2008)
Miyashita K, Nishikawa S, Beppu F, Tsukui T, Abe M, Hosokawa M, J. Sci. Food Agric., 91, 1166 (2011)
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[2] Campos VEB, Ricci-Junior E, Mansur CRE, J. Nanosci. Nanotechnol., 12, 2881 (2012)

[3] Lawrence MJ, Rees GD, Adv. Drug. Delivery Rev., 45, 89 (2000)

[4] Guyot A, Tauer K, Adv. Polym. Sci., 111, 43 (1994)

[5] Farago B, Richter D, Huang JS, Safran SA, Milner ST, Phys. Rev. Lett., 65, 3348 (1990)

[6] Sagitani H, Friberg S, J. Dispersion Sci. Technol., 1, 151 (1980)

[7] Attwood D, Mallon C, Taylor CJ, Int. J. Pharm., 84, R5 (1992)

[8] Aboofazeli R, Lawrence CB, Wicks SR, Lawrence MJ, Int. J. Pharm., 111, 63 (1994)

[9] Dora CL, Silva LFC, Putaux JL, Nishiyama Y, Pignot-Paintrand I, Borsali R, Lemos-Senna E, J. Nanosci. Nanotechnol., 8, 202 (2012)

[10] REES GD, ROBINSON BH, Adv. Mater., 5(9), 608 (1993)

[11] Tenjarla S, Crit. Rev. Ther. Drug Carr. Syst., 16, 461 (1999)

[12] Chang LC, Wu CL, Liu CW, Chou WH, Li PC, Tsai TR, J. Biomed. Nanotechnol., 7, 558 (2011)

[13] Jordan M, Nayel A, Brownlow B, Elbayoumi T, J. Biomed. Nanotechnol., 8, 944 (2012)

[14] Lococo D, Mora-Huertas CE, Fessi H, Zaanoun I, Elaissari A, J. Biomed. Nanotechnol., 8, 843 (2012)

[15] Lee KC, Maturo C, Rodriguez R, Nguyen HL, Shorr R, J. Nanosci. Nanotechnol., 11, 6642 (2011)

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[17] Delgado-Vargas F, Jimenez AR, Paredes-Lopez O, Crit. Rev. Food Sci. Nutr., 40, 173 (2000)

[18] Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K, Biochem. Biophys. Res. Commun., 332(2), 392 (2005)

[19] Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita K, Asia Pac. J. Clin. Nutr., 17, 196 (2008)

[20] Miyashita K, Nishikawa S, Beppu F, Tsukui T, Abe M, Hosokawa M, J. Sci. Food Agric., 91, 1166 (2011)

[21] Levine S, Bell GM, J. Colloid Interface Sci., 17, 838 (1962)