Effect of polymerization conditions on the size change of poly(ethylene glycol) hydrogel nanoparticles

Youn-Hee Kim; Minsub Chung; Bumsang Kim

Korea-Australia Rheology Journal, Vol.26, No.4, 401-404, November, 2014

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Effect of polymerization conditions on the size change of poly(ethylene glycol) hydrogel nanoparticles

Youn-Hee Kim, Minsub Chung, and Bumsang Kim^†

Department of Chemical Engineering, Hongik University, Seoul 121-791, Republic of Korea

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Suspension polymerization was used to prepare PEG homopolymer particles with nanometer size. In order to achieve the optimized reaction conditions for producing the smallest nanosized particles, the effects of various reaction conditions such as sonication, monomer concentration, molecular weight of monomer, and stabilizer concentration on the size of PEG hydrogel nanoparticles were investigated. Among these reaction conditions, sonication and the molecular weight of the monomer affected significantly the size reduction of PEG hydrogel nanoparticles, that is, the particle size decreased as sonication was conducted and the molecular weight of the monomer decreased. PEG homopolymer hydrogel nanoparticles having an average size of 182.1 nm were finally obtained with optimized reaction conditions.

Keywords:nanometer size;PEG homopolymer;hydrogel nanoparticles;suspension polymerization

[References]

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Suggs LJ, Shive MS, Garcia CA, Anderson JM, Mikos AG, J. Biomed. Mater. Res., 46, 22 (1999)
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[2] An SY, Bui MPN, Nam YJ, Han KN, Li CA, Choo J, Lee EK, Katoh S, Kumada Y, Seong GH, J. Colloid Interface Sci., 331(1), 98 (2009)

[3] Andreasen SO, Chong SF, Kryger MBL, Jensen BEB, Postma A, Alves MH, Stadler B, Goldie KN, Zelikin AN, Part. Part. Syst. Charact., 30(6), 514 (2013)

[4] Brooks BW, Chem. Eng. Technol., 33(11), 1737 (2010)

[5] Bryant SJ, Anseth KS, J. Biomed. Mater. Res., 59, 63 (2002)

[6] Dang TD, Kim YH, Kim HG, Kim GM, J. Ind. Eng. Chem., 18(4), 1308 (2012)

[7] Donini C, Robinson DN, Colombo P, Giordano F, Peppas NA, Int. J. Pharm., 245, 83 (2002)

[8] Dowding PJ, Vincent B, Colloid Sur. A-Physicochem. Eng. Asp., 161, 259 (2000)

[9] Hood RR, Shao CR, Omiatek DM, Vreeland WN, DeVoe DL, Pharm. Res., 30, 1597 (2013)

[10] Ikeda Y, Katamachi J, Kawasaki H, Nagasaki Y, Bioconjugate Chem., 24, 1824 (2013)

[11] Malana MA, Zohra R, Khan MS, Korea-Aust. Rheol. J., 24(3), 155 (2012)

[12] Langer R, Peppas NA, AIChE J., 49(12), 2990 (2003)

[13] Lee SC, Kwon IK, Park K, Adv. Drug Deliv. Rev., 65, 17 (2013)

[14] Leobandung W, Ichikawa H, Fukumori Y, Peppas NA, J. Appl. Polym. Sci., 87(10), 1678 (2003)

[15] Maya S, Sarmento B, Nair A, Rejinold NS, Nair SV, Jayakumar R, Curr. Pharm. Design, 19, 7203 (2013)

[16] Na YH, Korea-Aust. Rheol. J., 25(4), 185 (2013)

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[18] Peppas NA, Bures P, Leobandung W, Ichikawa H, Eur. J. Pharm. Biopharm., 50, 27 (2000)

[19] Piculell L, Dreyer JK, Nylander T, Karlsson OJ, ACS Appl. Mater. Interfaces, 3, 167 (2011)

[20] Suggs LJ, Shive MS, Garcia CA, Anderson JM, Mikos AG, J. Biomed. Mater. Res., 46, 22 (1999)

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[22] Wu Q, Han J, Lei T, Carbohydr. Polym., 102, 306 (2014)