화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.21, 1119-1126, January, 2015
DOI10.1016/j.jiec.2014.05.023  Export Citation
Clouding phenomenon of amphiphilic drug promazine hydrochloride solutions: Influence of pharmaceutical excipients
Malik Abdul Rub1, 2, †, Naved Azum1, 2, Dileep Kumar3, Farah Khan3, and Abdullah M. Asiri1, 2
  • 1Chemistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • 3Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India
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Various additives viz. hydrotropes, bile salts, fatty acid and cyclodextrin effect on the cloud point (CP) behavior of amphiphilic drug promazine hydrochloride (PMZ) in 1 mmol dm-3 14-4- 14 + 10 mmol dm-3 sodium phosphate (SP) buffer solutions have been investigated in the present study. These various additives are usually used as pharmaceutical excipients. The additives like anionic hydrotropes, bile salts and fatty acid salts increase the CP of PMZ, when added in low concentrations, whereas at high concentration, decrease it. Cationic and nonionic hydrotropes increase the CP of PMZ solutions at all concentration. Cyclodextrin behave like simple sugar is found to decrease the CP of the drug solutions at all concentrations. Gemini surfactant (14-4-14) has been found a better surfactant that can prevent clouding under physiological condition. It can thus be used as a drug-carrier system that increases the storage stability. The thermodynamic parameters are also evaluated: where △G°c is found to be negative and △H°c and T△S°c values are negative as well as positive depending upon type and nature of additive.
Keywords:Amphiphilic drugs;Cloud point;Hydrotropes;Bile salts;Fatty acid salts
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