Design, synthesis and characterization of a pH-sensitive DS/GM hydrogel

Zeynep Ozenir; Celile Demirbilek; Cemile Ozdemir Dinc

Macromolecular Research, Vol.23, No.11, 1012-1017, November, 2015

DOI10.1007/s13233-015-3144-8 Export Citation

Design, synthesis and characterization of a pH-sensitive DS/GM hydrogel

Zeynep Ozenir, Celile Demirbilek^†, and Cemile Ozdemir Dinc

Department of Chemistry, Division of Physical Chemistry, Faculty of Arts and Science, Mustafa Kemal University, TR-31034, Antakya, Turkiye, Turkey

E-mail:

Dextran sulfate/glycidyl methacrylate (DS/GM) hydrogels were synthesized by intermolecular side-chain reaction of DS hydroxyl groups with monomeric crosslinking agent, GM in aqueous solutions at 75 °C in the basic medium in this study. The optimum conditions of effective crosslinking for DS/GM system were determined with changing amounts of crosslinker and initiator (benzoyl peroxide, BPO). The swelling abilities of the hydrogels were explained with determining of certain structural parameters for the hydrogel such as equilibrium water content, percentages of gellation, and swelling ratio. pH dependent swelling behaviors of hydrogels were investigated and swelling ability at basic medium was higher than that at acidic medium. Surface morphologies of DS and its hydrogels were examined by scanning electron microscope (SEM) and they compared. Structures and thermal stabilities of DS/GM hydrogels were characterized by infrared (FTIR), thermal gravimetric analysis (TGA), differential thermal analysis (DTA), and Differential Scanning Calorimeter (DSC); effect of GM on crosslinking was investigated. The viscosities of DS/GM reaction products were recorded continuously as a function of time with rotary viscometer and gellation points of binary system reaction between DS and GM were determined via observed viscosity numbers, changes during reaction.

Keywords:dextran sulfate;glycidyl methacrylate;hydrogel;swelling;characterization

[References]

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Hashem M, Sharaf S, El-Hady MA, Hebeish A, Carbohydr. Polym., 95, 421 (2013)
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Sarmento B, Ferreira D, Veiga F, Ribeiro A, Carbohydr. Polym., 66, 1 (2006)

[Referenced By]

[1] Dragan ES, Chem. Eng. J., 243, 572 (2014)

[2] Omidian H, Hasherni SA, Askari F, Nafisi S, Iran. J. Sci. Technol., 3 (1994)

[3] Gregorova A, Saha N, Kitano T, Saha P, Carbohydr. Polym., 117, 559 (2015)

[4] Shi L, Yang N, Zhang H, Chen L, Tao L, Wei Y, Luo Y, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 48, 533 (2015)

[5] Moezzi AM, Fonn D, Varikooty J, Simpson TL, J. Opt. A-Pure Appl. Opt., 8(1), 19 (2014)

[6] Liu Y, Zhang F, Ru Y, Carbohydr. Polym., 117, 304 (2015)

[7] Kulkarni CV, Moinuddin Z, Patil-Sen Y, Littlefield R, Hood M, Int. J. Pharm., 479, 416 (2015)

[8] Farooqi ZH, Khan A, Siddiq M, Polym. Int., 60, 1481 (2011)

[9] Demirbilek C, Dinc CO, Desalination Water Treat., 2015, 1 (2015)

[10] Zamora-Mora V, Velasco D, Hernandez R, Mijangos C, Kumacheva E, Carbohydr. Polym., 111, 348 (2014)

[11] Corrente F, Amara HMA, Pacelli S, Paolicelli P, Casadei MA, Carbohydr. Polym., 92, 1033 (2013)

[12] Chiang CY, Chu CC, Carbohydr. Polym., 119, 18 (2015)

[13] He L, Yang J, Lu J, Xiao Y, Fan Y, Zhang X, Mater. Lett., 136, 41 (2014)

[14] Li Y, Liu C, Tan Y, Xu K, Lu C, Wang P, Carbohydr. Polym., 110, 87 (2014)

[15] Han X, Zheng Y, Munro CJ, Ji Y, Braunschweig AB, Curr. Opin. Biotechnol., 34, 41 (2015)

[16] Tan H, Marra KG, Materials, 3, 1746 (2010)

[17] Jalaja K, Kumar PA, Dey T, Kundu SC, James NR, Carbohydr. Polym., 114, 467 (2014)

[18] Pahimanolis N, Vesterinen AH, Rich J, Seppala J, Carbohydr. Polym., 82(1), 78 (2010)

[19] Maina NH, Tenkanen M, Maaheimo H, Juvonen R, Virkki L, Carbohydr. Res., 343, 1446 (2008)

[20] Leathers TD, in Biopolymers, Vandamme EJ, De Baets S, Steinbuchel A, Eds., Wiley-VCH, Weinheim, 2000, pp 229-321.

[21] Saboktakin MR, Tabatabaie R, Maharramov A, Ramazanov MA, Carbohydr. Polym., 81, 372 (2010)

[22] Anitha A, Deepagan VG, Rani VD, Menon D, Nair S, Jayakumar R, Carbohydr. Polym., 84, 1158 (2011)

[23] Saito A, Biochem. Biophys. Res. Commun., 4, 585 (2015)

[24] Desmedt SC, Lauwers A, Demeester J, Vansteenbergen MJ, Hennink WE, Roefs SP, Macromolecules, 28(14), 5082 (1995)

[25] Hennink WE, Talsma H, Borchert JCH, De Smedt SC, Demeester J, J. Control. Release, 39, 47 (1996)

[26] Dinu MV, Perju MM, Dragan ES, React. Funct. Polym., 71(8), 881 (2011)

[27] Guilherme MR, Reis AV, Takahashi SH, Rubira AF, Feitosa JP, Muniz EC, Carbohydr. Polym., 61, 464 (2005)

[28] Choi J, Yee AF, Laine RM, Macromolecules, 36(15), 5666 (2003)

[29] Vandijkwolthuis WN, Franssen O, Talsma H, Vansteenbergen MJ, Vandenbosch JJ, Hennink WE, Macromolecules, 28(18), 6317 (1995)

[30] Lo CW, Jiang HR, Polym. Eng. Sci., 50(2), 232 (2010)

[31] Demirbilek C, Dinc CO, Carbohydr. Polym., 90, 1159 (2012)

[32] Ramirez C, Rico M, Torres A, Barral L, Lopez J, Montero B, Eur. Polym. J., 44, 3035 (2008)

[33] Mahner C, Lechner MD, Nordmeier E, Carbohydr. Res., 331, 203 (2001)

[34] Rosca C, Novac O, Lisa G, Popa MI, Cell. Chem. Technol., 45, 185 (2011)

[35] Purama RK, Goswami P, Khan AT, Goyal A, Carbohydr. Polym., 76, 30 (2009)

[36] Kim SH, Chu CC, J. Biomed. Mater. Res., 49, 517 (2000)

[37] Kim B, La Flamme K, Peppas NA, J. Appl. Polym. Sci., 89(6), 1606 (2003)

[38] Sadeghi M, Soleimani F, J. Biomater. Nanobiotechnol., 3, 310 (2012)

[39] Siegel RA, Firestone BA, Macromolecules, 21, 3254 (1988)

[40] Rudzinski WE, Chipuk T, Dave AM, Kumbar SG, Aminabhavi TM, J. Appl. Polym. Sci., 87(3), 394 (2003)

[41] Grillet AM, Gloe LM, Wyatt NB, in Rheology, InTech, Croatia, 2012, p 65.

[42] Wang LF, Shen SS, Lu SC, Carbohydr. Polym., 52, 389 (2003)

[43] Thakur A, Wanchoo RK, Singh P, Chem. Biochem. Eng. Q., 25, 471 (2012)

[44] Enomoto-Rogers Y, Iwata T, Carbohydr. Polym., 87, 1933 (2012)

[45] Hashem M, Sharaf S, El-Hady MA, Hebeish A, Carbohydr. Polym., 95, 421 (2013)

[46] Othman MBH, Akil HM, Rasib SZM, Khan A, Ahmad Z, Ind. Crop. Prod., 66, 178 (2015)

[47] Sarmento B, Ferreira D, Veiga F, Ribeiro A, Carbohydr. Polym., 66, 1 (2006)