Dendritic porous SnO2/SiO2@polymer nanospheres for pH-controlled styptic drug release

Na Cao; Xin Xie; Yu Zhang; Yanbao Zhao; Liuqin Cao; Lei Sun

Journal of Industrial and Engineering Chemistry, Vol.34, 9-13, February, 2016

DOI10.1016/j.jiec.2015.10.040 Export Citation

Dendritic porous SnO2/SiO2@polymer nanospheres for pH-controlled styptic drug release

Na Cao, Xin Xie¹, Yu Zhang^†, Yanbao Zhao^†, Liuqin Cao, and Lei Sun

Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475004, China
¹Henan Vocational & Technical College, Zhengzhou 450046, China

E-mail:,

Dendritic porous tin oxide/silica (DTS) nanospheres (NSs) were prepared by emulsion-condensation route. DTS NSs have an average diameter of 80 nm and possess accessible center-radial large pore channels, which endow them high surface area, less drug diffusion resistance and more mass transport. SnO2 quantum dots (QDs) embedded in silica skeleton can be used to track the drug release behavior. DTS NSs were coated by chitosan/polymethacrylic acid and polymer shell would make them achieve great loading capacity and pH-sensitive release for aminomethylbenzoic acid (AMBA).

Keywords:Silica nanospheres;Fluorescence;pH-controlled release;AMBA

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[Referenced By]

[1] Yu YJ, Xing JL, Pang JL, Jiang SH, Lam KF, Yang TQ, Xue QS, Zhang K, Wu P, ACS Appl. Mater. Interfaces, 6, 22655 (2014)

[2] Niu DC, Liu ZJ, Li YS, Luo XF, Zhang JY, Gong JP, Shi JL, Adv. Mater., 26(29), 4947 (2014)

[3] Shi B, Zhang H, Qiao SZ, Bi J, Dai S, Adv. Healthc. Mater., 3, 1839 (2014)

[4] Du X, Shi BY, Liang J, Bi JX, Dai S, Qiao SZ, Adv. Mater., 25(41), 5981 (2013)

[5] Deng Z, Zhen Z, Hu X, Wu S, Xu Z, Chu PK, Biomaterials, 32, 4976 (2011)

[6] Zheng HQ, Huang ZH, Che SN, J. Chem. Soc.-Dalton Trans., 41, 5038 (2012)

[7] Feng W, Nie W, He C, Zhou X, Chen L, Qiu K, Wang W, Yin Z, ACS Appl. Mater. Interfaces, 6, 8447 (2014)

[8] Luo Z, Cai KY, Hu Y, Li JH, Ding XW, Zhang BL, Xu DW, Yang WH, Liu P, Adv. Mater., 24(3), 431 (2012)

[9] Zhu YF, Shi JL, Shen WH, Dong XP, Feng JW, Ruan ML, Li YS, Angew. Chem.-Int. Edit., 44, 5083 (2005)

[10] Tricoli A, Biosensors, 2, 221 (2012)

[11] Chen F, Shi Z, Liu M, Chem. Commun., 2095 (2000)

[12] Zhu Y, Chen J, Li H, Zhu Y, Xu J, Sens. Actuators B-Chem., 193, 320 (2014)

[13] Singh LP, Singh NP, Srivastava SK, J. Chem. Soc.-Dalton Trans., 44, 657 (2015)

[14] Sun L, Wang Y, Jiang T, Zheng X, Zhang J, Sun J, Sun C, Wang S, ACS Appl. Mater. Interfaces, 5, 103 (2013)

[15] Fang W, Wang ZY, Zong SF, Chen H, Zhu D, Zhong Y, Cui YP, Biosens. Bioelectron., 57, 10 (2014)

[16] Hu XX, Wang Y, Peng B, Chem. Asian J., 9, 319 (2014)

[17] Zhang WB, He S, Liu Y, Geng QQ, Ding GL, Guo MC, Deng YF, Zhu JL, Li JQ, Cao YS, ACS Appl. Mater. Interfaces, 6, 11783 (2014)

[18] Li Z, Shen W, Wang Z, Xiang X, Zu X, Wei Q, Wang L, J. Sol-Gel Sci. Technol., 49, 196 (2009)