화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.35, 75-82, March, 2016
DOI10.1016/j.jiec.2015.12.004  Export Citation
Synthesis of high porous electrospun hollow TiO2 nanofibers for bone tissue engineering application
Surya Prasad Adhikari1, 2, Hem Raj Pant2, 3, Hamouda M. Mousa1, 4, Joshua Lee1, 5, Han Joo Kim6, Chan Hee Park1, 7, †, and Cheol Sang Kim1, 7, †
  • 1Department of Bionanosystem Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea
  • 2Institute of Engineering, Tribhuvan University, Kathmandu, Nepal
  • 3Research Institute for Next Generation, Kalanki, Kathmandu, Nepal
  • 4Department of Engineering Materials and Mechanical Design, Faculty of Engineering, South Valley University, Qena 83523, Egypt
  • 5, Korea
  • 6Division of Convergence Technology Engineering, Engineering College, Chonbuk National University, Jeonju 561-756, Republic of Korea
  • 7Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea
E-mail:,
Highly porous, hollow TiO2 nanofibers (NFs) were fabricated through coaxial nozzle electrospinning using a polymer sol-gel solution of CaCO3 and TiO2 precursor. Hollow and porous TiO2 NFs were obtained by etching CaCO3 on calcined TiO2 fibers using dilute HCl. Characterization of the as-synthesized materials were performed using FE-SEM and XRD before and after 24 h of bio-mineralization. The in vitro cell culture test was performed using MC3T3-E1 osteoblast cells to assess cell response of the different NFs. The results suggested that as-synthesized porous nanotubes have better biocompatibility for bone regeneration and implantations compared to other nonporous TiO2 nanorods or NFs.
Keywords:TiO2;Coaxial electrospinning;Nanotubes;Biomaterials;Bone tissue engineering
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