pH-responsive "liquid marbles" can be prepared by adsorption of a hydrophobic fluorinated fatty acid powder, 2H,2H,3H,3H-heptadecafluoroundecanoic acid (HFUA) onto the surface of water droplet. These stabilized liquid marbles can float on an acidic bulk aqueous phase. When NaOH aqueous solution is added to the bulk phase, the liquid marble disintegrates due to ionization of the carboxy group in HFUA.