화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.24, No.7, 602-608, July, 2016
DOI10.1007/s13233-016-4077-6  Export Citation
pH and redox dual stimuli-responsive injectable hydrogels based on carboxymethyl cellulose derivatives
Yueqin Shen1, Xian Li1, 2, Yawen Huang2, Guanjun Chang2, Ke Cao2, Junxiao Yang2, Renyi Zhang1, 3, Xueying Sheng1, 3, and Xu Ye1, 3, †
  • 1School of Materials Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, P. R. China
  • 2State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology, Mianyang, 621010, P. R. China
  • 3, China
E-mail:
pH and redox dual stimuli-responsive injectable hydrogels were prepared by cross-linking oxidized carboxymethyl cellulose (oxi-CMC) with 3,3′-dithiobis (propionohydrazide) (DTP) via Schiff base reaction under physiological condition. The hydrogels showed good performance such as tunable gelling time, appropriate rheology properties, high swelling ratio and low degradation rate. In vitro release studies confirmed that bovine serum albumin (BSA) as a model drug exhibited a sustainable release at pH 7.4 and an accelerated release under a lower pH 5.0 and/or reducing environments. The results signified that oxi-CMC/DTP hydrogels could be an attractive candidate for drug delivery system, tissue engineering or cell scaffold materials.
Keywords:carboxymethyl cellulose;injectable hydrogel;pH responsive;redox responsive
  1. Liu Y, Liang D, J. Control. Release, 152, e63 (2011)
  2. Popescu MT, Mourtas S, Pampalakis G, Antimisiaris SG, Tsitsilianis C, Biomacromolecules, 12(8), 3023 (2011)
  3. He L, Liang H, Lin L, Shah BR, Li Y, Chen Y, Colloids Surf. B: Biointerfaces, 126, 288 (2015)
  4. Ozenir Z, Demirbilek C, Dinc CO, Macromol. Res., 23(11), 1012 (2015)
  5. Berko S, Marod M, Bodnar M, Eros G, Hartmann P, Szentner K, Szabo-Revesz P, Kemeny L, Borbely J, Csanyi E, Eur. Polym. J., 49, 2511 (2013)
  6. McKay CA, Pomrenke RD, McLane JS, Schaub NJ, DeSimone EK, Ligon LA, Gilbert RJ, ACS Appl. Mater. Interfaces, 6, 1424 (2014)
  7. Censi R, Di Martino P, Vermonden T, Hennink WE, J. Control. Release, 161, 680 (2012)
  8. Vermonden T, Censi R, Hennink WE, Chem. Rev., 112(5), 2853 (2012)
  9. Peppas NA, Hilt JZ, Khademhosseini A, Langer R, Adv. Mater., 18(11), 1345 (2006)
  10. Sung Y, Kim TH, Lee B, Macromol. Res., 24(2), 143 (2016)
  11. Songkroh T, Xie H, Yu W, Liu X, Sun G, Xu X, Ma X, Macromol. Res., 23(1), 53 (2015)
  12. Lu SY, Liu MZ, Ni BL, Chem. Eng. J., 160(2), 779 (2010)
  13. Weng L, Rostamzadeh P, Nooryshokry N, Le HC, Golzarian J, Acta Biomater., 9, 6823 (2013)
  14. Jin R, Teixeira LSM, Dijkstra PJ, Van Blitterswijk CA, Karperien M, Feijen J, Biomaterials, 31, 3103 (2010)
  15. Van Tomme SR, Storm G, Hennink WE, Int. J. Pharm., 355, 1 (2008)
  16. Ko DY, Shinde UP, Yeon B, Jeong B, Prog. Polym. Sci, 38, 672 (2013)
  17. Guan JJ, Hong Y, Ma ZW, Wagner WR, Biomacromolecules, 9(4), 1283 (2008)
  18. Balakrishnan B, Jayakrishnan A, Biomaterials, 26, 3941 (2005)
  19. Lee F, Chung JE, Kurisawa M, J. Control. Release, 134, 186 (2009)
  20. Chitprasert P, Sutaphanit P, J. Agric. Food Chem., 62, 12641 (2014)
  21. Shlyapnikov YM, Shlyapnikova EA, Morozov VN, Anal. Chem., 86, 2082 (2014)
  22. Perko T, Markocic E, Knez Z, Skerget M, J. Chem. Eng. Data, 56(11), 4040 (2011)
  23. Siritientong T, Aramwit P, Macromol. Res., 23(9), 861 (2015)
  24. Hu X, Li H, Luo S, Liu T, Jiang Y, Liu S, J. Polym. Sci. A: Polym. Chem., 4, 695 (2013)
  25. Hu XL, Tian J, Liu T, Zhang GY, Liu SY, Macromolecules, 46(15), 6243 (2013)
  26. Halacheva SS, Adlam DJ, Hendow EK, Freemont TJ, Hoyland J, Saunders BR, Biomacromolecules, 15(5), 1814 (2014)
  27. Hudson SP, Langer R, Fink GR, Kohane DS, Biomaterials, 31, 1444 (2010)
  28. Su W, Chen Y, Lin F, Acta Biomater., 6, 3044 (2010)
  29. Deng GH, Tang CM, Li FY, Jiang HF, Chen YM, Macromolecules, 43(3), 1191 (2010)
  30. Deng G, Li F, Yu H, Liu F, Liu C, Sun W, Jiang H, Chen Y, ACS Macro Lett., 1, 275 (2012)
  31. He L, Jiang Y, Tu C, Li G, Zhu B, Jin C, Zhu Q, Yan D, Zhu X, Chem. Commun., 46, 7569 (2010)
  32. Corbett PT, Leclaire J, Vial L, West KR, Wietor JL, Sanders JKM, Otto S, Chem. Rev., 106(9), 3652 (2006)
  33. Gyarmati B, Vajna B, Nemethy A, Laszlo K, Szilagyi A, Macromol. Biosci., 13, 633 (2013)
  34. Prestwich GD, Marecak DM, Marecek JF, Vercruysse KP, Ziebell MR, J. Control. Release, 53, 93 (1998)
  35. Hofreiter BT, Alexander BH, Wolff IA, Anal. Chem., 27, 1930 (1955)
  36. Li L, Wang N, Jin X, Deng R, Nie S, Sun L, Wu Q, Wei Y, Gong C, Biomaterials, 35, 3903 (2014)
  37. Antunes JC, Oliveira JM, Reis RL, Soria JM, Gomez-Ribelles JL, Mano JF, J. Biomed. Mater. Res. A, 94, 856 (2010)
  38. Bae KH, Wang L, Kurisawa M, J. Mater. Chem. B, 1, 5371 (2013)