Safflower contains two color pigments. Yellow pigment is the safflor yellow which is water-soluble, and red pigment is the carthamin which is water-insoluble. However, cathamin is soluble in alcohol or alkalic solution. The pH conditions of carthamin extraction from safflower were examined using several alkalic solution such as sodium carbonate(Na2CO3), potassium carbonate(K2CO3), sodium hydroxide, and potassium hydroxide(KOH). Based on this study, the best extraction solvent is Na2CO3 solution. The best conditions of extraction with pH for each solution were pH 11.0 for Na2CO3 and K2CO3, and pH 11.5 for NaOH and KOH. Therefore, the optimum condition of carthamin extraction in this experiment is pH 11.0 using Na2CO3, and extraction time of Na2CO3 is 30 minute.