Ionized liquids (ILs) @LiFe5O8/multiwall carbon nanotubes (MWCNTs) magnetic nanohybrid was synthesized as an enhanced electrode material for the ultrasensitive detection of the endocrine-disrupting compound bisphenol AP (BPAP) for the first time. The as-prepared ILs@LiFe5O8/MWCNTs nanohybrid can facilitate electron transport and provide a larger surface area that can effectively increase the quantity of adsorbed BPAP. In the phosphate buffer (PBS) of pH 5.0, the constructed sensor exhibited linear relationships with BPAP concentrations ranging from 1.034 x 10(-9) to 2.069 x 10(-6) mol L-1 and a detection limit of 8.197 x 10(-10) mol L-1(S/N = 3). Meanwhile, it also showed good reproducibility, stability, and antiinterference, indicating that the ILs@LiFe5O8/MWCNTs nanohybrid is a promising sensing platform for the trace-level analysis of BPAP in real samples.