화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.45, 182-188, January, 2017
DOI10.1016/j.jiec.2016.09.021  Export Citation
Completely disintegrable redox-responsive poly(amino acid) nanogels for intracellular drug delivery
Chan Woo Park1, 2, Hee-Man Yang2, Min-Ah Woo1, 3, Kwang Se Lee1, 4, and Jong-Duk Kim1, 4, †
  • 1Department of Chemical and Biomolecular Engineering (BK21 program), Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea
  • 2Decontamination & Decommissioning Research Division, Korea Atomic Energy Research Institute, Daedeok-daero 989-111 Yuseong-gu, Daejeon, Republic of Korea
  • 3Food Safety Research Group, Korea Food Research Institute, Bundang-Ku, Gyeonggi-Do, Republic of Korea
  • 4, Korea
E-mail:
We report a disulfide cross-linked poly(amino acid) nanogel that is completely disintegrable in the intracellular reductive environment by cleavage of the disulfide cross-links. A short-poly(ethylene glycol)-grafted poly(succinimide) was synthesized as an amphiphilic prepolymer to prepare poly(amino acid) nanogels that consisted of a hairy PEG shell and a disulfide cross-linked poly(amino acid) core. The nanogels were prepared by chemical conversion of the hydrophobic core of the cross-linkedmicelles into a hydrophilic poly(aspartic acid) network. The nanogels disintegrated into fully water-soluble and biocompatible residues in the reductive condition. Post-endocytic disintegration of the nanogel improved nuclear translocation and efficacy of an anticancer drug.
Keywords:Nanogel;Disulfide;Drug delivery;Reduction-responsive
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