Engineered chitosan-xanthan gum biopolymers effectively adhere to cells and readily release incorporated antiseptic molecules in a sustained manner

Jieun Kim; Jangsun Hwang; Youngmin Seo; Yeonho Jo; Jaewoo Son; Jonghoon Choi

Journal of Industrial and Engineering Chemistry, Vol.46, 68-79, February, 2017

DOI10.1016/j.jiec.2016.10.017 Export Citation

Engineered chitosan-xanthan gum biopolymers effectively adhere to cells and readily release incorporated antiseptic molecules in a sustained manner

Jieun Kim, Jangsun Hwang, Youngmin Seo, Yeonho Jo, Jaewoo Son, and Jonghoon Choi^†

School of Integrative Engineering, Chung-Ang University, Seoul 06974, Republic of Korea

E-mail:

The polyelectrolyte complexes that contain anionic xanthan gum and cationic chitosan formed or coalesced into biopolymeric scaffolds. To increase the viscosity and adherent properties of the prepared scaffolds, chitosan.xanthan gum microspheres were prepared by coacervation. The coalesced biopolymer was mixed with CHX to form injectable antibacterial hydrogels. We successfully prepared a biocompatible, antiseptic, chitosan.xanthan gum-based biopolymer with a potential to be used as an effective local antiseptic for acute or chronic periodontitis.

Keywords:Chitosan;Xanthan gum;Chlorohexidine;Biopolymer;Antiseptic agent

[References]

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Thakur A, Monga S, Wanchoo RK, Chem. Biochem. Eng. Q., 28, 11 (2014)
Cetin S, Erdincler A, Water Sci. Technol., 50, 49 (2004)
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Peppas NA, Pharm. Acta Helv., 60, 110 (1985)
Hayashi T, Kanbe H, Okada M, Suzuki M, Ikeda Y, Onuki Y, Kaneko T, Sonobe T, Int. J. Pharm., 304, 91 (2005)

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[2] Kissel T, Li Y, Unger F, Adv. Drug Deliv. Rev., 54, 99 (2002)

[3] Li Y, Rodrigues J, Tomas H, Chem. Soc. Rev., 41, 2193 (2012)

[4] Bensaid W, Triffitt JT, Blanchat C, Oudina K, Sedel L, Petite H, Biomaterials, 24, 2497 (2003)

[5] Wang F, Li Z, Khan M, Tamama K, Kuppusamy P, Wagner WR, Sen CK, Guan J, Acta Biomater., 6, 1978 (2010)

[6] Guvendiren M, Lu HD, Burdick JA, Soft Matter, 8, 260 (2012)

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[8] Geckil H, Xu F, Zhangd X, Moon S, Demirci U, Nanomedicine, 5, 469 (2010)

[9] Soppimath KS, Aminabhavi TM, Dave AM, Kumbar SG, Rudzinski WE, Drug Dev. Ind. Pharm., 28, 957 (2002)

[10] Bueno VB, Bentini R, Catalani LH, Petri DF, Carbohydr. Polym., 92, 1091 (2013)

[11] Garcia-Ochoa F, Santos VE, Casas JA, Gomez E, Biotechnol. Adv., 18, 549 (2000)

[12] Kar R, Mohapatra S, Bhanja S, Das D, Barik B, Iran. J. Pharm. Res., 9, 13 (2010)

[13] Quinn FX, Hatakeyama T, Takahashi M, Hatakeyama H, Polymer, 35(6), 1248 (1994)

[14] Zatz JL, Knapp S, J. Pharm. Sci., 73, 468 (1984)

[15] Muzzarelli RAA, Carbohydr. Polym., 3, 53 (1983)

[16] Felt O, Buri P, Gurny R, Drug Dev. Ind. Pharm., 24, 979 (1998)

[17] Dutta PK, Dutta J, Tripathi V, J. Sci. Ind. Res., 63, 20 (2004)

[18] Felse PA, Panda T, Bioprocess Eng., 20, 505 (1999)

[19] Kumar MNVR, Muzzarelli RAA, Muzzarelli C, Sashiwa H, Domb AJ, Chem. Rev., 104(12), 6017 (2004)

[20] Sashiwa H, Aiba SI, Prog. Polym. Sci, 29, 887 (2004)

[21] Zheng LY, Zhu JF, Carbohydr. Polym., 54, 527 (2003)

[22] Badwan AA, Rashid I, Omari MM, Darras FH, Mar. Drugs, 13, 1519 (2015)

[23] Duttagupta DS, Jadhav VM, Kadam VJ, Curr. Drug Deliv., 12, 369 (2015)

[24] Islam MA, Park TE, Reesor E, Cherukula K, Hasan A, Firdous J, Singh B, Kang SK, Choi YJ, Park IK, Cho CS, Curr. Pharm. Des., 21, 4285 (2015)

[25] Cheung RC, Ng TB, Wong JH, Chan WY, Mar. Drugs, 13, 5156 (2015)

[26] Ferrero F, Periolatto M, J. Nanosci. Nanotechnol., 12, 4803 (2012)

[27] Despond S, Espuche E, Cartier N, Domard A, J. Appl. Polym. Sci., 98(2), 704 (2005)

[28] Zhao Q, Qian JW, An QF, Gao CJ, Gui ZL, Jin HT, J. Membr. Sci., 333(1-2), 68 (2009)

[29] Zhang Y, Wei W, Lv P, Wang L, Ma G, Eur. J. Pharm. Biopharm., 77, 11 (2011)

[30] Liu G, Shi Z, Kuriger T, Hanton LR, Simpson J, Moratti SC, Robinson BH, Athanasiadis T, Valentine R, Wormald PJ, Robinson S, Macromol. Symp., 279, 151 (2009)

[31] Lin YS, Okamoto Y, Minami S, J. Biomed. Nanotechnol., 6, 247 (2010)

[32] Kweon DK, Song SB, Park YY, Biomaterials, 24, 1595 (2003)

[33] Zhang Y, Zhang Y, Preparation of kappa-carrageenan-chitosan polyelectrolyte gel beads, Zhongguo Zhong Yao Za Zhi 37 (2012) 466.

[34] Birch NP, Schiffman JD, Langmuir, 30(12), 3441 (2014)

[35] Veiga IG, Moraes AM, J. Appl. Polym. Sci., 124, E154 (2012)

[36] Chellat F, Tabrizian M, Dumitriu S, Chornet E, Rivard CH, Yahia L, J. Biomed. Mater. Res., 53, 592 (2000)

[37] Chu CH, Kumagai H, Nakamura K, J. Appl. Polym. Sci., 60(7), 1041 (1996)

[38] Chu H, Sakiyama T, Yano T, Biosci. Biotechnol. Biochem., 59, 717 (1995)

[39] Kulkarni N, Wakte P, Naik J, Int. J. Pharm. Invest., 5, 73 (2015)

[40] Al-Akayleh F, Al Remawi M, Salem MS, Badwan A, J. Expients Food Chem., 5, 140 (2014)

[41] Caddeo C, Nacher A, Diez-Sales O, Merino-Sanjuan M, Fadda AM, Manconi M, J. Microencapsul., 31(7), 694 (2014)

[42] Dumitriu S, Chornet E, Biotechnol. Prog., 13(5), 539 (1997)

[43] Dumitriu S, Magny P, Montane D, Vidal PF, Chornet E, J. Bioact. Compat. Polym., 9, 184 (1994)

[44] Magnin D, Lefebvre J, Chornet E, Dumitriu S, Carbohydr. Polym., 55, 437 (2004)

[45] Jones CG, Periodontol. 2000 15 (1997) 55.

[46] Huynh TT, Padois K, Sonvico F, Rossi A, Zani F, Pirot F, Doury J, Falson F, Eur. J. Pharm. Biopharm., 74, 255 (2010)

[47] Paolantonio M, D'Angelo M, Grassi RF, Perinetti G, Piccolomini R, Pizzo G, Annunziata M, D'Archivio D, D'Ercole S, Nardi G, Guida L, J. Periodontol., 79, 271 (2008)

[48] Rao MA, Flow and functional models for rheological properties of fluid foods, Rheology of Fluid and Semisolid Foods, Springer, US, 2007 p. 27.

[49] Mitsoulis E, Rheol. Rev., The British Society of Rheology., 44 (2007)

[50] Bingham EC, Fluidity and Plasticity, Mcgraw-Hill Book Company, Inc., 1922.

[51] Herschel W, Bulkley R, Konsistenzmessungen von Gummi-Benzollosungen, Kolloid-Zeitschrift, 39, 291 (1926)

[52] Casson N, in: Mill CC (Ed.), Rheology of Disperse Systems, Pergamon, London, 1959.

[53] Beris A, Tsamopoulos J, Armstrong R, Brown R, J. Fluid Mech., 158, 219 (1985)

[54] Ferraris CF, Hackley VA, Guide to Rheological Nomenclature for Liquid-based Particle Systems NIST Special Publication 946, National Institute of Standards and Technology, 2001 31.

[55] Daniel G, Yoan C, Zoltan P, Yves P, Bingham-papanastasiou and approximate parallel models comparison for the design of magneto-rheological valves, 2014 IEEE/ASME International Conference on Advanced Intelligent Mechatronics (AIM) (2014) 168.

[56] Korsmeyer RW, Gurny R, Doelker E, Buri P, Peppas NA, Int. J. Pharm., 15, 25 (1983)

[57] Argin-Soysal S, Kofinas P, Lo YM, Food Hydrocolloids, 23, 202 (2009)

[58] Hamman JH, Mar. Drugs, 8, 1305 (2010)

[59] Desai KG, Park HJ, Drug Deliv., 13, 39 (2006)

[60] Thakur A, Monga S, Wanchoo RK, Chem. Biochem. Eng. Q., 28, 11 (2014)

[61] Cetin S, Erdincler A, Water Sci. Technol., 50, 49 (2004)

[62] Hamcerencu M, Desbrieres J, Popa M, Khoukh A, Riess G, Polymer, 48(7), 1921 (2007)

[63] Popa N, Novac O, Profire L, Lupusoru CE, Popa MI, Mater. Med., 21, 1241 (2010)

[64] Peppas NA, Pharm. Acta Helv., 60, 110 (1985)

[65] Hayashi T, Kanbe H, Okada M, Suzuki M, Ikeda Y, Onuki Y, Kaneko T, Sonobe T, Int. J. Pharm., 304, 91 (2005)