화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.47, 194-201, March, 2017
DOI10.1016/j.jiec.2016.11.032  Export Citation
Properties of poloxamer 407 and polysorbate mixed micelles: Influence of polysorbate hydrophobic chain
Dejan Cirin†, Veljko Krstonosic, and Mihalj Posa
  • Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkiva 3, 21000 Novi Sad, Serbia
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In the present study, binary mixed micelles of poloxamer 407 and a homologous series of polysorbate surfactants (polysorbate 20, polysorbate 60, polysorbate 80, polysorbate 85) were investigated. Rubingh’s model was applied to determine the physicochemical parameters of the poloxamer/polysorbate binary systems. The obtained negative values of the interaction parameter and excess Gibbs energy showed the existence of synergism. By comparing the values of the investigated parameters, and the values of micropolarity measurements, it was noticed that the inclusion of polysorbate surfactants with longer and more saturated hydrophobic chains leads to improved packing in the micellar interior and stronger interactions.
Keywords:Poloxamer;Polysorbate;Mixed micelles;Regular solution theory;Interactions
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