화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.48, 108-118, April, 2017
DOI10.1016/j.jiec.2016.12.026  Export Citation
Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres
Jae Min Choi1, Benel Lee2, Daham Jeong2, Kyeong Hui Park2, Eun-Ji Choi3, Yong-Joon Jeon4, Someshwar D. Dindulkar1, Eunae Cho1, Sun Hee Do3, Kyungho Lee4, Im-Soon Lee4, Seyeon Park5, Bong-Hyun Jun6, Jae-Hyuk Yu7, and Seunho Jung8, 2, †
  • 1Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul, Korea
  • 2Department of Systems Biotechnology, Microbial Carbohydrate Resource Bank (MCRB) Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul, Republic of Korea
  • 3Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea
  • 4Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea
  • 5Department of Applied Chemistry, Dongduk Women’s University, Seoul, Republic of Korea
  • 6Department of Systems Biotechnology, Konkuk University, Seoul, Republic of Korea
  • 7Departments of Bacteriology and Genetics, and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, WI, United States, USA
  • 8Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul, Republic of Korea
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Hydroxypropyl cyclosophoraose-pullulan (HPCys-Pul) microspheres were designed as a novel hybrid system of biocompatible pullulan matrice and pendant hydroxypropyl cyclosophoraoses with drug complexing ability. The HPCys-Pul microspheres were prepared by emulsion crosslinking method, and characterized using thermogravimetric analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, and solid state NMR spectroscopy. By virtue of hydroxypropyl cyclosophoraoses, the developed microspheres can encapsulate 4.2-fold more naproxen than pullulan microspheres. Korsmeyer-Peppas model was introduced for describing release kinetics. In vivo naproxen release analysis was carried out in Sprague-Dawley (SD) rats. From those results HPCys-Pul microsphere will be a promising platform for controlled drug delivery.
Keywords:Pullulan;Hydroxypropyl cyclosophoraose;Microsphere;Drug delivery;Naproxen
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