Formation of stable adhesive water-in-oil emulsions using a phospholipid and cosurfactants

Hyunjun Kim; KyuHan Kim; Hyun-Ro Lee; HyeongChan Jo; Dae-woong Jeong; Jiheun Ryu; Dae-Gab Gweon; Siyoung Q. Choi

Journal of Industrial and Engineering Chemistry, Vol.55, 198-203, November, 2017

DOI10.1016/j.jiec.2017.06.046 Export Citation

Formation of stable adhesive water-in-oil emulsions using a phospholipid and cosurfactants

Hyunjun Kim^{1, 2}, KyuHan Kim², Hyun-Ro Lee², HyeongChan Jo³, Dae-woong Jeong³, Jiheun Ryu¹, Dae-Gab Gweon^{1, †}, and Siyoung Q. Choi^{2, †}

¹Department of Mechanical Engineering, KAIST, Daejeon 305-701, Republic of Korea
²Department of Chemical and Biomolecular engineering, KAIST, Daejeon 305-701, Republic of Korea
³Department of Bio and Brain Engineering, KAIST, Daejeon 305-701, Republic of Korea

E-mail:,

The use of adhesive water-in-oil (W/O) emulsions covered with phospholipids have been limited due to their poor stability. We suggest a new and simple method to create adhesive W/O emulsions stabilized by 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) with two different cosurfactants (docosahexaenoic acid (DHA) and sorbitan oleate (SPAN 80)). Although an adhesive W/O emulsion with DOPC is typically unstable because of its molecular structure, we demonstrate that the addition of cosurfactants whose molecular shapes could be complementary to that of DOPC far better stabilizes W/O emulsions and indeed leads to the production of adhesive emulsions by the formation of a bilayer between two monolayers of each droplet surface.

Keywords:Water-in-oil emulsion stability;Phospholipid emulsion;Adhesive emulsion;Lipid bilayer;Cosurfactant

[References]

Leal-Calderon F, Schmitt V, Bibette J, Emulsion Science: Basic Principles, Springer, New York, 2007.
Collins-Gold LC, Lyons RT, Bartholow LC, Adv. Drug Deliv. Rev., 5(3), 189 (1990)
Djagny VB, Wang Z, Xu S, Crit. Rev. Food Sci. Nutr., 41(6), 481 (2001)
Dickinson E, Food Hydrocoll., 17(1), 25 (2003)
Dickinson E, Curr. Opin. Colloid Interface Sci., 15(1-2), 40 (2010)
Dickinson E, McClements DJ, Advances in Food Colloids, Springer Science & Business Media, 1995.
McClements DJ, Decker EA, Park Y, Weiss J, Crit. Rev. Food Sci. Nutr., 49(6), 577 (2009)
Muller RH, Petersen RD, Hommoss A, Pardeike J, Adv. Drug Deliv. Rev., 59(6), 522 (2007)
Leal LG, Phys. Fluids, 16(6), 1833 (2004)
Taylor P, Adv. Colloid Interface Sci., 75(2), 107 (1998)
Kunieda H, Shinoda K, J. Colloid Interface Sci., 107(1), 107 (1985)
Bancroft WD, J. Phys. Chem., 17(6), 501 (1912)
Pichot R, Watson RL, Norton IT, Int. J. Mol. Sci., 14(6), 11767 (2013)
Zhang F, Proctor A, J. Am. Oil Chem. Soc., 74(7), 869 (1997)
Kabalnov A, Tarara T, Arlauskas R, Weers J, J. Colloid Interface Sci., 184(1), 227 (1996)
Kabalnov A, Weers J, Arlauskas R, Tarara T, Langmuir, 11(8), 2966 (1995)
Knoth A, Scherze I, Muschiolik G, Food Hydrocolloids, 19(3), 635 (2005)
Ushikubo FY, Cunha RL, Food Hydrocolloids, 34, 145 (2014)
Choi SQ, Steltenkamp S, Zasadzinski JA, Squires TM, Nat. Commun., 2, 312 (2011)
Kim K, Choi SQ, Zell ZA, Squires TM, Zasadzinski JA, Proc. Natl. Acad. Sci. U. S. A., 110(33), E3054 (2013)
Walther TC, Farese RV, Annu. Rev. Biochem., 81, 687 (2012)
Martin S, Parton RG, Nat. Rev. Mol. Cell Biol., 7(5), 373 (2006)
Beltramo PJ, Van Hooghten R, Vermant J, Soft Matter, 12(19), 4324 (2016)
Jeong DW, Jang H, Choi SQ, Choi MC, Sci. Rep., 6(1), 38158 (2016)
Chen IA, Salehi-Ashtiani K, Szostak JW, J. Am. Chem. Soc., 127(38), 13213 (2005)
Noireaux V, Libchaber A, Proc. Natl. Acad. Sci. U. S. A., 101(51), 17669 (2004)
Pietrini AV, Luisi PL, Chembiochem, 5(8), 1055 (2004)
Holden MA, Needham D, Bayley H, J. Am. Chem. Soc., 129(27), 8650 (2007)
Thiam AR, Bremond N, Bibette J, Langmuir, 28(15), 6291 (2012)
Villar G, Graham AD, Bayley H, Science, 340(6128), 48 (2013)
Fukuhira Y, Yabu H, Ijiro K, Shimomura M, Soft Matter, 5(10), 2037 (2009)
Johansson D, Bergenstahl B, J. Am. Oil Chem. Soc., 72(2), 205 (1995)
Thiam AR, Bremond N, Bibette J, Phys. Rev. Lett., 107, 068301 (2011)
Poulin P, Bibette J, Langmuir, 14(22), 6341 (1998)
Heron AJ, Thompson JR, Cronin B, Bayley H, Wallace MI, J. Am. Chem. Soc., 131(5), 1652 (2009)
Heron AJ, Thompson JR, Mason AE, Wallace MI, J. Am. Chem. Soc., 129(51), 16042 (2007)
Li GZ, Friberg SE, J. Am. Oil Chem. Soc., 59(12), 569 (1982)
Williams JM, Langmuir, 7(7), 1370 (1991)
Alvarez NJ, Walker LM, Anna SL, J. Colloid Interface Sci., 333(2), 557 (2009)
Davies EKRJT, Interfacial Phenomena, Academic Press, New York, 1963.
Pautot S, Frisken BJ, Cheng JX, Xie XS, Weitz DA, Langmuir, 19(24), 10281 (2003)

[1] Leal-Calderon F, Schmitt V, Bibette J, Emulsion Science: Basic Principles, Springer, New York, 2007.

[2] Collins-Gold LC, Lyons RT, Bartholow LC, Adv. Drug Deliv. Rev., 5(3), 189 (1990)

[3] Djagny VB, Wang Z, Xu S, Crit. Rev. Food Sci. Nutr., 41(6), 481 (2001)

[4] Dickinson E, Food Hydrocoll., 17(1), 25 (2003)

[5] Dickinson E, Curr. Opin. Colloid Interface Sci., 15(1-2), 40 (2010)

[6] Dickinson E, McClements DJ, Advances in Food Colloids, Springer Science & Business Media, 1995.

[7] McClements DJ, Decker EA, Park Y, Weiss J, Crit. Rev. Food Sci. Nutr., 49(6), 577 (2009)

[8] Muller RH, Petersen RD, Hommoss A, Pardeike J, Adv. Drug Deliv. Rev., 59(6), 522 (2007)

[9] Leal LG, Phys. Fluids, 16(6), 1833 (2004)

[10] Taylor P, Adv. Colloid Interface Sci., 75(2), 107 (1998)

[11] Kunieda H, Shinoda K, J. Colloid Interface Sci., 107(1), 107 (1985)

[12] Bancroft WD, J. Phys. Chem., 17(6), 501 (1912)

[13] Pichot R, Watson RL, Norton IT, Int. J. Mol. Sci., 14(6), 11767 (2013)

[14] Zhang F, Proctor A, J. Am. Oil Chem. Soc., 74(7), 869 (1997)

[15] Kabalnov A, Tarara T, Arlauskas R, Weers J, J. Colloid Interface Sci., 184(1), 227 (1996)

[16] Kabalnov A, Weers J, Arlauskas R, Tarara T, Langmuir, 11(8), 2966 (1995)

[17] Knoth A, Scherze I, Muschiolik G, Food Hydrocolloids, 19(3), 635 (2005)

[18] Ushikubo FY, Cunha RL, Food Hydrocolloids, 34, 145 (2014)

[19] Choi SQ, Steltenkamp S, Zasadzinski JA, Squires TM, Nat. Commun., 2, 312 (2011)

[20] Kim K, Choi SQ, Zell ZA, Squires TM, Zasadzinski JA, Proc. Natl. Acad. Sci. U. S. A., 110(33), E3054 (2013)

[21] Walther TC, Farese RV, Annu. Rev. Biochem., 81, 687 (2012)

[22] Martin S, Parton RG, Nat. Rev. Mol. Cell Biol., 7(5), 373 (2006)

[23] Beltramo PJ, Van Hooghten R, Vermant J, Soft Matter, 12(19), 4324 (2016)

[24] Jeong DW, Jang H, Choi SQ, Choi MC, Sci. Rep., 6(1), 38158 (2016)

[25] Chen IA, Salehi-Ashtiani K, Szostak JW, J. Am. Chem. Soc., 127(38), 13213 (2005)

[26] Noireaux V, Libchaber A, Proc. Natl. Acad. Sci. U. S. A., 101(51), 17669 (2004)

[27] Pietrini AV, Luisi PL, Chembiochem, 5(8), 1055 (2004)

[28] Holden MA, Needham D, Bayley H, J. Am. Chem. Soc., 129(27), 8650 (2007)

[29] Thiam AR, Bremond N, Bibette J, Langmuir, 28(15), 6291 (2012)

[30] Villar G, Graham AD, Bayley H, Science, 340(6128), 48 (2013)

[31] Fukuhira Y, Yabu H, Ijiro K, Shimomura M, Soft Matter, 5(10), 2037 (2009)

[32] Johansson D, Bergenstahl B, J. Am. Oil Chem. Soc., 72(2), 205 (1995)

[33] Thiam AR, Bremond N, Bibette J, Phys. Rev. Lett., 107, 068301 (2011)

[34] Poulin P, Bibette J, Langmuir, 14(22), 6341 (1998)

[35] Heron AJ, Thompson JR, Cronin B, Bayley H, Wallace MI, J. Am. Chem. Soc., 131(5), 1652 (2009)

[36] Heron AJ, Thompson JR, Mason AE, Wallace MI, J. Am. Chem. Soc., 129(51), 16042 (2007)

[37] Li GZ, Friberg SE, J. Am. Oil Chem. Soc., 59(12), 569 (1982)

[38] Williams JM, Langmuir, 7(7), 1370 (1991)

[39] Alvarez NJ, Walker LM, Anna SL, J. Colloid Interface Sci., 333(2), 557 (2009)

[40] Davies EKRJT, Interfacial Phenomena, Academic Press, New York, 1963.

[41] Pautot S, Frisken BJ, Cheng JX, Xie XS, Weitz DA, Langmuir, 19(24), 10281 (2003)