Optimization of the extraction of phytochemicals from black mulberry (Morus nigra L.) leaves

Natasa Nastic; Isabel Borrás-Linares; Jesús Lozano-Sánchez; Jaroslava Svac-Gajic; Antonio Segura-Carretero

Journal of Industrial and Engineering Chemistry, Vol.68, 282-292, December, 2018

DOI10.1016/j.jiec.2018.07.055 Export Citation

Optimization of the extraction of phytochemicals from black mulberry (Morus nigra L.) leaves

Natasa Nastic¹, Isabel Borrás-Linares², Jesús Lozano-Sánchez^{2, 3}, Jaroslava Svac-Gajic^{1, †}, and Antonio Segura-Carretero^{2, 3}

¹Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia
²Functional Food Research and Development Centre (CIDAF), Health Science Technological Park, Avda. del Conocimiento s/n, Bioregion building, 18016 Granada, Spain
³Department of Analytical Chemistry, Faculty of Sciences, University of Granada, Avda. Fuentenueva s/n, 18071 Granada, Spain

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This study aimed to compare the chemical composition of Morus nigra leaves extracts, obtained by maceration, accelerated solvent (ASE) and supercritical fluid extraction (SFE) under different extraction conditions. With regards to chemical composition, mainly phenolic acids and flavonoids were identified. HPLC-ESI-QTOF-MS allowed the identification of 13 new compounds reported in M. nigra leaves for the first time. ASE as a fast, green and innovative approach, seems to be the best choice for extracting compounds of different polarities within the shortest extraction time. The present study also highlights the potential application of M. nigra extracts as constituents of new added-value formulations.

Keywords:Morus nigra leaves;Phytochemicals;ASE;SFE;HPLC-ESI-QTOF-MS

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[Referenced By]

[1] Chen PN, Chu SC, Chiou HL, Kuo WH, Chiang CL, Hsieh YS, Cancer Lett., 235, 248 (2006)

[2] Song W, Wang HJ, Bucheli P, Zhang PF, Wei DZ, Lu YH, J. Agric. Food Chem., 57, 9133 (2009)

[3] Koyuncu F, Chem. Nat. Compd., 40, 367 (2004)

[4] Li HX, Jo E, Myung CS, Kim YH, Yang SY, Nat. Prod. Res., 1 (2017).

[5] Qin J, Fan M, He J, Wu XD, Peng LY, Su J, Cheng X, Li Y, Kong LM, Li RT, Zhao QS, Nat. Prod. Res., 29, 1711 (2015)

[6] Agarwal S, Kanwar K, Plant Cell Rep., 26, 177 (2007)

[7] Volpato GT, Calderon IDMP, Sinzato S, Campos KEP, Rudge MVC, Damasceno DC, J. Ethnopharmacol., 138, 691 (2011)

[8] Miranda MA, Vieira GD, Alves MS, Yamamoto CH, de Pinho JJRG, de Sousa OV, Brasil. Hosp. Univ. Rev., 36, 61 (2010)

[9] Memon AA, Memon N, Luthria DL, Bhanger MI, Pitafi AA, Pol. J. Food Nutr. Sci., 60, 25 (2010)

[10] Nastic N, Svarc-Gajic J, Delerue-Matos C, Barroso MF, Soares C, Moreira MM, Morais S, Maskovic P, Srcek VG, Slivac, Radosevic K, Ind. Crop. Prod., 111, 579 (2018)

[11] Radojkovic MM, Zekovic ZP, Vidovic SS, Kocar DD, Maskovic PZ, Hem. Ind., 66, 547 (2012)

[12] Sanchez-Salcedo EM, Tassotti M, Del Rio D, Hernandez F, Martinez JJ, Mena P, Food Chem., 212, 250 (2016)

[13] Svarc-Gajic J, Sampling and Sample Preparation in Analytical Chemistry, Nova Science Publishers, New York, 2012.

[14] Mustafa A, Turner C, Anal. Chim. Acta, 703, 8 (2011)

[15] Knez Z, Skerget M, Hrncic MK, Separation, Extraction and Concentration Processes in the Food, USA, pp.3 2013.

[16] Mishima K, Kawakami R, Yokota H, Harada J, Kato T, Irie K, Mishima K, Fujiwara M, Matsuyama K, Mustofa S, Salim A, Solvent Extr. Res. Dev., 20, 79 (2013)

[17] Yang C, Xu YR, Yao WX, J. Agric. Food Chem., 50, 846 (2002)

[18] Radojkovic M, Zekovic Z, Maskovic P, Vidovic S, Mandic A, Misan A, Durovic S, J. Supercrit. Fluids, 117, 50 (2016)

[19] Rodriguez-Perez C, Quirantes-Pine R, Fernandez-Gutierrez A, Segura-Carretero A, Food Res. Int., 54, 1519 (2013)

[20] Melguizo-Melguizo D, Diaz-de-Cerio E, Quirantes-Pine R, Svarc-Gajic J, Segura-Carretero A, J. Funct. Foods, 10, 192 (2014)

[21] Hancock RD, Chudek JA, Walker PG, Pont SD, Viola R, Phytochemistry, 69, 1850 (2008)

[22] Jimenez-Sanchez C, Lozano-Sanchez J, Marti N, Saura D, Valero M, Segura-Carretero A, Fernandez-Gutierrez A, Food Chem., 182, 282 (2015)

[23] Yang J, Zhang X, Jin Q, Gu L, Liu X, Li J, Ni Y, Nat. Prod. Res., 31, 1091 (2017)

[24] Abbas GM, Abdel Bar FM, Baraka HN, Gohar AA, Lahloub MF, Nat. Prod. Res., 28, 952 (2014)

[25] Jeong JY, Liu Q, Kim SB, Jo YH, Mo EJ, Yang HH, Song DH, Hwang BY, Lee MK, Molecules, 20, 8730 (2015)

[26] Dugo P, Donato P, Cacciola F, Germano MP, Rapisarda A, Mondello L, J. Sep. Sci., 32, 3627 (2009)

[27] Mena P, Sanchez-Salcedo EM, Tassotti M, Martinez JJ, Hernandez F, Del Rio D, Food Res. Int., 89, 1116 (2016)

[28] Bao T, Li Y, Xie J, Sun C, Li X, Pu Y, Chen W, Food Res. Int., 103, 326 (2017)

[29] Zhang L, Tu ZC, Yuan T, Wang H, Fu ZF, Wen QH, Wang XQ, Ind. Crop. Prod., 56, 223 (2014)

[30] Yan S, Liang Y, Zhang J, Chen Z, Liu CM, Fungal Genet. Biol., 81, 229 (2015)

[31] Jimenez-Sanchez C, Lozano-Sanchez J, Rodriguez-Perez C, Segura-Carretero A, Fernandez-Gutierrez A, J. Food Compos. Anal., 46, 78 (2016)

[32] Hamburger M, Baumann D, Adler S, Phytochem. Anal., 15, 46 (2004)

[33] Spigno G, Trarnelli L, De Faveri DM, J. Food Eng., 81(1), 200 (2007)

[34] Herrero M, Temirzoda TN, Segura-Carretero A, Quirantes R, Plaza M, Ibanez E, J. Chromatogr. A, 1218, 7511 (2011)

[35] Chan SW, Lee CY, Yap CF, Aida WW, Ho CW, Int. Food Res. J., 16, 203 (2009)

[36] Toubane A, Rezzoug SA, Besombes C, Daoud K, Ind. Crop. Prod., 97, 620 (2017)

[37] Espinosa-Pardo FA, Martinez J, Martinez-Correa HA, J. Supercrit. Fluids, 93, 2 (2014)