On-demand generation of heat and free radicals for dual cancer therapy using thermal initiator- and gold nanorod-embedded PLGA nanocomplexes

Guru Karthikeyan Thirunavukkarasu; G.R. Nirmal; Hwangjae Lee; Mingyu Lee; Inkyu Park; Jae Young Lee

Journal of Industrial and Engineering Chemistry, Vol.69, 405-413, January, 2019

DOI10.1016/j.jiec.2018.09.051 Export Citation

On-demand generation of heat and free radicals for dual cancer therapy using thermal initiator- and gold nanorod-embedded PLGA nanocomplexes

Guru Karthikeyan Thirunavukkarasu¹, G.R. Nirmal¹, Hwangjae Lee¹, Mingyu Lee¹, Inkyu Park², and Jae Young Lee^{1, 3, †}

¹School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea
²Department of Biomedical Science and BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju 501-746, Republic of Korea
³Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea

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Dual cancer therapy is an attractive strategy that can generate synergistic effects and also reduce drug-related side effects. Here, we developed multifunctional nanocomplexes capable of remote on-demand production of hyperthermia and free radicals in response to near infrared (NIR) light irradiation To this end, thermal initiator and gold nanorods were embedded in nano-sized temperature- responsive poly(lactic acid-co-glycolic acid). In vitro studies demonstrated controllable heat and radical production from the nanocomplexes with NIR and effective eradication of CT26 colon cancer cells with our nanocomplexes. Hence, our smart nanomaterial will potentially contribute precise and effective dual cancer treatment.

Keywords:Cancer therapy;Nanomedicine;Free radicals;Photothermal;Stimuli responsive material

[References]

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[Referenced By]

[1] Hong EJ, Choi DG, Shim MS, Acta Pharm. Sin. B, 6(4), 297 (2016)

[2] Cheng L, Wang C, Feng LZ, Yang K, Liu Z, Chem. Rev., 114(21), 10869 (2014)

[3] Peer D, Karp JM, Hong S, FaroKHzad OC, Margalit R, Langer R, Nat. Nanotechnol., 2(12), 751 (2007)

[4] Shi J, Kantoff PW, Wooster R, Farokhzad OC, Nat. Rev. Cancer, 17(1), 20 (2017)

[5] Jha S, Sharma PK, Malviya R, Achiev. Life Sci., 10(2), 161 (2016)

[6] Xu L, Cheng L, Wang C, Peng R, Liu Z, Polym. Chem., 5(5), 1573 (2014)

[7] Ribeiro LNS, Okada EMP, Carvalho FK, Stuani MBS, Borsatto MC, Silva FWGP, Kuchler EC, Oral Surg., 10(3), 174 (2017)

[8] Noh MS, Lee S, Kang H, Yang JK, Lee H, Hwang D, Lee JW, Jeong S, Jang Y, Jun BH, Jeong DH, Kim SK, Lee YS, Cho MH, Biomaterials, 45, 81 (2015)

[9] Aioub M, Panikkanvalappil SR, El-Sayed MA, ACS Nano, 11(1), 579 (2017)

[10] Riley RS, Day ES, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 9(4), e1449 (2017)

[11] Wang WQ, Wang L, Li Y, Liu S, Xie ZG, Jing XB, Adv. Mater., 28(42), 9320 (2016)

[12] Shen S, Tang H, Zhang X, Ren J, Pang Z, Wang D, Gao H, Qian Y, Jiang X, Yang W, Biomaterials, 34(12), 3150 (2013)

[13] Fujiwara N, Som AT, Pham LDD, Lee BJ, Mandeville ET, Lo EH, Arai K, Neurosci. Lett., 633, 7 (2016)

[14] Valko M, Jomova K, Rhodes CJ, Kuca K, Musilek K, Arch. Toxicol., 90(1), 1 (2016)

[15] Levy JG, Semin. Oncol., 21, 4 (1994)

[16] Dolmans DEJGJ, Fukumura D, Jain RK, Nat. Rev. Cancer, 3(5), 380 (2003)

[17] Shen S, Zhu C, Huo D, Yang M, Xue J, Xia Y, Angew. Chem.-Int. Edit., 56(30), 8801 (2017)

[18] Wang XQ, Gao F, Zhang XZ, Angew. Chem.-Int. Edit., 56, 9029 (2017)

[19] Qin SY, Zhang AQ, Cheng SX, Rong L, Zhang XZ, Biomaterials, 112, 234 (2017)

[20] Zand B, Westin SN, Coleman RL, Textbook of Uncommon Cancer, John Wiley & Sons, Ltd., pp.663 2017.

[21] Naahidi S, Jafari M, Edalat F, Raymond K, Khademhosseini A, Chen P, J. Control. Release, 166(2), 182 (2013)

[22] Cheng R, Meng F, Deng C, Klok HA, Zhong Z, Biomaterials, 34(14), 3647 (2013)

[23] Sau TK, Murphy CJ, Langmuir, 20(15), 6414 (2004)

[24] Orendorff CJ, Murphy CJ, J. Phys. Chem. B, 110(9), 3990 (2006)

[25] Chu CH, Wang YC, Tai LA, Wu LC, Yang CS, J. Mater. Chem., 20(16), 3260 (2010)

[26] Lee H, Chung S, Kim MG, Lee LP, Lee JY, Adv. Healthcare Mater., 5, 1638 (2016)

[27] Balavoine GGA, Geletii YV, Nitric Oxide, 3(1), 40 (1999)

[28] Kong G, Braun RD, Dewhirst MW, Cancer Res., 60, 4440 (2000)

[29] Nakamura Y, Mochida A, Choyke PL, Kobayashi H, Bioconjugate Chem., 27(10), 2225 (2016)

[30] Sousa F, Cruz A, Fonte P, Pinto IM, Neves-Petersen MT, Sarmento B, Sci. Rep., 7(1), 3736 (2017)

[31] Jastrzebska AM, Kurtycz P, Olszyna A, Karwowska E, Miaskiewicz-Peska E, Zaleska-Radziwill M, Doskocz N, Basiak D, Int. J. Appl. Ceram. Technol., 12(6), 1157 (2015)

[32] Jaque D, Maestro LM, del Rosal B, Haro-Gonzalez P, Benayas A, Plaza JL, Rodriguez EM, Sole JG, Nanoscale, 6(16), 9494 (2014)

[33] Darani MK, Bastani S, Ghahari M, Kardar P, Mohajerani E, Prog. Org. Coat., 104, 97 (2017)

[34] Kuo WS, Chang CN, Chang YT, Yang MH, Chien YH, Chen SJ, Yeh CS, Angew. Chem.-Int. Edit., 49, 2711 (2010)

[35] Gramlich WM, Holloway JL, Rai R, Burdick JA, Nanotechnology, 25(1), 014004 (2014)

[36] Yoshida Y, Itoh N, Saito Y, Hayakawa M, Niki E, Free Radical Res., 38(4), 375 (2004)

[37] Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC, J. Control. Release, 190, 485 (2014)

[38] Li F, Chen W, You B, Liu Y, Yang S, Yuan Z, Zhu W, Li J, Qu C, Zhou Y, Zhou X, Liu C, Zhang X, ACS Appl. Mater. Interfaces, 8(47), 32146 (2016)