키토산 기반 분자 각인 고분자 필름의 슐린닥 흡착 및 방출 특성

윤연흠; 윤순도; 나재운; 심왕근; Yeon-Hum Yoon; Soon-Do Yoon; Jae Woon Nah; Wang Geun Shim

Applied Chemistry for Engineering, Vol.30, No.2, 233-240, April, 2019

DOI10.14478/ace.2019.1004 Export Citation

키토산 기반 분자 각인 고분자 필름의 슐린닥 흡착 및 방출 특성

Adsorption and Release Characteristics of Sulindac on Chitosan-based Molecularly Imprinted Functional Polymer Films

윤연흠, 윤순도^{1, †}, 나재운 ², 심왕근^{2, †}

전남대학교 공과대학 에너지자원공학과
¹전남대학교 공학대학 화공생명공학과
²순천대학교 공과대학 고분자공학과

Yeon-Hum Yoon, Soon-Do Yoon^{1, †}, Jae Woon Nah², and Wang Geun Shim^{2, †}

Department of Energy and Resources Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
¹Department of Chemical and Biomolecular Engineering, Chonnam National University, Yeosu 59626, Republic of Korea
²Department of Polymer Science and Engineering, Sunchon National University, Suncheon, Jeollanam-do 57922, Republic of Korea

E-mail:,

초록

분자인식기술은 특정 분자를 고분자 매트릭스에 각인시켜 특정 분자의 선택성을 높이는 기술로 관심을 받아왔다. 이 연구에서는 Sulindac (SLD)을 각인시킨 키토산 기반 약물 전달용 필름의 흡착 및 방출 특성을 가소제, 온도, pH를 변화 시켜 실험하고 그 결과를 관련 모델식으로 해석하였다. SLD 각인 고분자 필름의 약물 흡착은 Freundlich와 Sips식이 Langmuir식보다 더 잘 설명되었고 binding site 에너지 분포 함수는 SLD와 고분자 필름 간의 흡착 특성관계를 이해하는데 유용하였다. 그리고 SLD 각인 고분자 필름의 약물 방출은 Fickian 확산 거동을 보인 반면, 인공피부조건에서는 non-Fickian 확산 거동을 따랐다.

Molecular recognition technology has attracted considerable attention for improving the selectivity of a specific molecule by imprinting it on a polymer matrix. In this study, adsorption and release characteristics of chitosan based drug delivery films imprinted with sulindac (SLD) were investigated in terms of the plasticizer, temperature and pH and the results were also interpreted by the related mathematical models. The adsorption characteristics of target molecules on SLD-imprinted polymer films were better explained by the Freundlich and Sips equation than that of the Langmuir equation. The binding site energy distribution function was also useful for understanding the adsorption relationship between target molecules and polymer films. The drug release of SLD-imprinted polymer films followed the Fickian diffusion mechanism, whereas the drug release using artificial skin followed the non-Fickian diffusion behavior.

Keywords:Adsorption;Modelling;Molecularly imprinted polymer;Release;Sulindac

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[1] Prausnitz1 MR, Langer R, Nat. Biotechnol., 26, 1261 (2008)

[2] Lam PL, Gambari R, J. Control. Release, 178, 25 (2014)

[3] Nir Y, Paz A, Sabo A, Potasman I, Am. J. Trop. Med. Hyg., 68, 341 (2003)

[4] Kermode M, Health Promot. Int., 19, 95 (2004)

[5] Rosen H, Abribat T, Nat. Rev. Drug Discov., 4, 381 (2005)

[6] Vigerust DJ, Future Neurol., 11, 113 (2016)

[7] Zahoor A, Sharma S, Khuller GK, Int. J. Antimicrob. Agents, 26, 298 (2005)

[8] LaVan DA, McGuire T, Langer R, Nat. Biotechnol., 21, 1184 (2003)

[9] Tao SL, Desai TA, Adv. Drug Deliv. Rev., 55, 315 (2003)

[10] Gupta P, Vermani K, Garg S, Drug Discov. Today, 7, 569 (2002)

[11] Banerjee S, Chattopadhyay P, Ghosh A, Datta P, Veer V, Int. J. Adhes. Adhes., 50, 70 (2014)

[12] Ryu KE, Kim YB, Polym. Sci. Technol., 9(6), 464 (1998)

[13] Nair LS, Laurencin CT, Prog. Polym. Sci, 32, 762 (2007)

[14] Tian H, Yan J, Rajulu AV, Xiang A, Luo X, Int. J. Biol. Macromol., 96, 518 (2017)

[15] Wu YH, Luo XG, Li W, Song R, Li J, Li Y, Li B, Liu SL, Food Chem., 197, 250 (2016)

[16] John MJ, Thomas S, Carbohydr. Polym., 71, 343 (2008)

[17] Altiok D, Altiok E, Tihminlioglu F, J. Mater. Sci. -Mater. Med., 21, 2227 (2010)

[18] Raju G, Haris MRHM, Polym. Test, 53, 1 (2016)

[19] Chen H, Hu X, Chen E, Wu S, McClements DJ, Liu S, Li B, Li Y, Food Hydrocolloids, 61, 662 (2016)

[20] Yang Y, Niu H, Zhang H, ACS Appl. Mater. Interfaces, 8, 15741 (2016)

[21] Zhao X, Chen L, Li B, Food Chem., 255, 226 (2018)

[22] Maciazek-Jurczyk M, Sulkowska A, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 136, 265 (2015)

[23] Yun YH, Lee CM, Kim YS, Yoon SD, Food Res. Int., 100, 377 (2017)

[24] Do DD, Adsorption Analysis: Equilibria and Kinetics, 11-148, Imperial College Press, London, UK (1998).

[25] Jaroniec M, Madey R, Physical Adsorption on Heterogeneous Solids, 1-143, Elsevier, Amsterdam, Netherlands (1988).

[26] Rudzinski W, Everett D, Adsorption of Gases on Heterogeneous Solid Surfaces, 1-111, Academic Press, London, UK (1991).

[27] Nahm SW, Shim WG, Park YK, Kim SC, Chem. Eng. J., 210, 500 (2012)

[28] Hwang KJ, Im C, Cho DW, Yoo SJ, Lee JW, Shim WG, RSC Adv., 2, 3034 (2012)

[29] Hwang KJ, Park JY, Kim YJ, Kim G, Choi C, Jin S, Kim N, Lee JW, Shim WG, Sep. Sci. Technol., 50(12), 1757 (2015)

[30] Hwang KJ, Shim WG, Kim Y, Kim G, Choi C, Kang SO, Cho DW, Phys. Chem. Chem. Phys., 17, 21974 (2015)

[31] Rubilar JF, Cruz RMS, Zuniga RN, Khmelinskii I, Vieira MC, Int. J. Biol. Macromol., 104, 197 (2017)

[32] Ritger PL, Peppas NA, J. Control. Release, 5, 37 (1987)

[33] Ivanov AE, Kozynchenko OP, Mikhalovska LI, Tennison SR, Jungvid H, Gun’ko VM, Mikhalovsky SV, Phys. Chem. Chem. Phys., 14, 16267 (2012)