The characteristics of multiphase dynamic mass transfer play a big role in gaining understanding and controllability of gas- liquid two-phase chemical absorption processes. In the present work, dynamic coupling of mass transfer and chemical reaction for Taylor flow in a serpentine microchannel was investigated by an online method. The dynamic changes of gas bubbles, key mass transfer parameters, i.e., k(L)a, k(L), and a, and the enhancement factor were measured and calculated, where the three changing stages were found under different operating conditions of QG (2-5.5 mL), QL (1-2.5 mL), and WMEA (1-3 wt %). On the basis of the experimental results, a modified van Baten's model was proposed to predict mass transfer performance for both CO2-H2O and CO2-MEA systems, and the correlation coefficients were 0.95 and 0.96, respectively. The correlations also suggested the net physical mass transfer performance in CO2-MEA system could be reasonably separated from the chemical absorption process.