Air supply system is an important subsystem in the fuel cell engine with strongly nonlinear and coupling interactions. There are strong coupling problems between air flow and pressure in the air supply system, such as the air compressor and electronic throttle opening. This paper introduces a novel coordination control strategy for the air supply system of high power fuel cell engine in heavy truck. It consists of feed-forward and internal model decoupling control (IMC) with tracking an optimized working line of centrifugal air compressor. The strategy can maintain good control effect for model matching and model mismatching with robustness. The working efficiency of the centrifugal air compressor could be significantly increased and avoid the phenomenon of surge by the coordination control strategy. At the same time, the output current of fuel cell engine can meet the load requirement which has the short response time and good follow effect. (C) 2019 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.