경피약물전달을 위한 아세트아미노펜 각인 기능성 전분 기반 바이오 소재 제조 및 방출 특성

김한성; 김경중; 이시연; 조은비; 강현욱; 윤순도; Han-Seong Kim; Kyeong-Jung Kim; Si-Yeon Lee; Eun-Bi Cho; Hyun-Wook Kang; Soon-Do Yoon

Applied Chemistry for Engineering, Vol.32, No.3, 299-304, June, 2021

DOI10.14478/ace.2021.1027 Export Citation

경피약물전달을 위한 아세트아미노펜 각인 기능성 전분 기반 바이오 소재 제조 및 방출 특성

Preparation and Release Properties of Acetaminophen Imprinted Functional Starch based Biomaterials for Transdermal Drug Delivery

김한성, 김경중, 이시연, 조은비, 강현욱^{1, †}, 윤순도^†

전남대학교 화공생명공학과
¹전남대학교 기계공학부

Han-Seong Kim, Kyeong-Jung Kim, Si-Yeon Lee, Eun-Bi Cho, Hyun-Wook Kang^{1, †}, and Soon-Do Yoon^†

Department of Biomolecular and Chemical Engineering, Chonnam National University, Jeonnam 59626, South Korea
¹Department of Mechanical Engineering, Chonnam National University, Gwangju 61186, South Korea

E-mail:,

초록

본 연구에서는 mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (S), glycerol (GL), melanin (MEL)을 이용하여 광열 효과가 있는 기능성 acetaminophen (AP) 각인 MBS 기반 바이오 소재를 제조하고 약물 방출 특성을 조사하였다. 제조된 AP 각인 바이오 소재의 물리화학적 특성은 FE-SEM과 FT-IR을 통해 분석하였다. 또한, NIR (near infrared) laser (1.5 W/cm2) 조사에 따른 기능성 바이오 소재의 광열 효과 및 AP 방출 특성을 조사하였다. 바이오 소재에 NIR laser를 조사하였을 때, MEL이 첨가 바이오 소재는 첨가하지 않은 바이오 소재보다 2배 이상 높은 온도상승을 보였다. 표준 버퍼 용액과 인공 피부를 사용하여 기능성 AP 각인 바이오 소재의 AP 방출 특성 조사결과, NIR laser를 조사하였을 때, MEL 첨가 바이오 소재는 첨가하지 않은 바이오 소재보다 AP 방출율이 1.2배 높은 것을 확인하였다. 이 결과로부터, 기능성 바이오 소재는 급성 진통 치료를 위한 바이오 소재로 활용될 수 있을 것으로 판단된다.

This study focuses on the preparation of acetaminophen (AP) imprinted functional biomaterials for a transdermal drug delivery using mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (S) as a crosslinking agent, glycerol (GL) as a plasticizer, and melanin (MEL) as a photothermal agent. The prepared AP imprinted biomaterials were characterized using FE-SEM and their physical properties were evaluated. The photothermal effect and AP release property for functional biomaterials were examined with the irradiation of near infrared (NIR) laser (1.5 W/cm2). When the NIR laser was irradiated on functional biomaterials with/without the addition of MEL, the temperature of MEL added biomaterial increased from 25 ℃ to 41 ℃, whereas the biomaterial without MEL increased from 25 ℃ to 28 ℃. Results indicate that there is the photothermal effect of prepared biomaterial with the addition of MEL. Based on the results, AP release properties were evaluated using standard buffer solutions and artificial skin. It was found that AP release rates of MEL added AP loaded biomaterials were 1.2 times faster than those of MEL non-added AP loaded biomaterials when irradiating with NIR laser. We envision that the developed functional biomaterials can be utilized for an acute pain-killing treatment.

Keywords:Transdermal drug delivery;Melanin;Photothermal effect;Acetaminophen;Release properties

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[2] Tak HY, Yun YH, Lee CM, Yoon SD, Carbohydr. Polym., 208, 261 (2019)

[3] Hsu SH, Hung KC, Chen CE, J. Mater. Chem. B, 4(47), 7493 (2016)

[4] Banerjee S, Chattopadhyay P, Ghosh A, Datta P, Veer V, Int. J. Adhes. Adhes., 50, 70 (2014)

[5] Bochove BV, Grijpma DW, J. Biomater. Sci-Polym. Ed., 30(2), 77 (2019)

[6] Hamad K, Kaseem M, Ko YG, Deri F, Polym. Sci. Ser. A, 56(6), 812 (2014)

[7] Nair LS, Laurencin CT, Prog. Polym. Sci, 32(8-9), 762 (2007)

[8] Almasi H, Ghanbarzadeh B, Entezami AA, Int. J. Biol. Macromol., 46(1), 1 (2010)

[9] Lu DR, Xiao CM, Xu SJ, Express Polym. Lett., 3(6), 366 (2009)

[10] Reddy N, Yang Y, Food Chem., 118(3), 702 (2010)

[11] Wu C, Jiang P, Li W, Guo H, Wang J, Chen J, Prausnitz MR, Wang ZL, Adv. Funct. Mater., 30(3), 190737 (2020)

[12] J. Drug, J. Drug, Azmana M, Mahmood S, Hilles AR, Mandal UK, Al-Japairai KAS, Raman S, J. Drug Deliv. Sci. Technol., 101877 (2020).

[13] Zhou X, Hao Y, Yuan L, Pradhan S, Shrestha K, Pradhan O, Liu H, Li W, Chin. Chem. Lett., 29(12), 1713 (2018)

[14] Kim HS, Kim KJ, Lee MW, Lee SY, Yun YH, Shim WG, Int. J. Biol. Macromol., 161, 763 (2020)

[15] Li Y, Chen SM, Int. J. Electrochem. Sci., 7(3), 2175 (2012)

[16] Lim EB, Vy TA, Lee SW, J. Mater. Chem. B, 8(10), 2096 (2020)

[17] Abid S, Hussain T, Nazir A, Zahir A, Khenoussi N, Mater. Res. Express, 5(8), 085017 (2018)

[18] Kim M, Kim HS, Kim MA, Ryu H, Jeong HJ, Lee CM, Macromol. Biosci., 17(5) (2017)

[19] Liu YL, Ai KL, Liu JH, Deng M, He YY, Lu LH, Adv. Mater., 25(9), 1353 (2013)

[20] Roy S, Rhim JW, Colloids Surf. B: Biointerfaces, 176, 317 (2019)

[21] Kim HS, Yun YH, Shim WG, Yoon SD, Int. J. Biol. Macromol., 175, 217 (2021)

[22] Sajjan S, Kulkarni G, Yaligara V, Lee K, Karegoudar TB, J. Microbiol. Biotechnol., 20(11), 1513 (2010)

[23] Stainsack J, Mangrich AS, Maia CM, Machado VG, dos Santos JC, Nakag S, Inorg. Chim. Acta., 356, 243 (2003)

[24] El-Shahawy AS, Ahmed SM, Sayed NK, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 66(1), 143 (2007)

[25] Binev IG, Vassileva-Boyadjieva P, Binev YI, J. Mol. Struct., 447(3), 235 (1998)