The cytotoxic dosage of exposed drug waste is frequently discharging on aquatic surfaces via wastewater treatment plants and pharma industries. Early detection of these drug wastes with a reliable and accurate are in great need. In this report, a noble metal effectively doped on oxidized one-dimensional (1D) singlewalled carbon nanotube and abundant oxygen functional groups presenting two-dimensional (2D) graphene oxide on its surface, and hydrophobic cavities are the promising selector towards electrochemical oxidation of Naproxen (NPZ). A hybrid nanocomposite Au@f-CNT/GO was engineered by the ultrasoundassist sonication method and employed for the ultra-quantification of the therapeutic drug NPZ. In addition, various physicochemical and analytical techniques were utilized to confirm the successful formation of composite and principal detection of NPZ. Au@f-CNT/GO fabricated glassy carbon electrode exhibits a low resistance and higher electrocatalytic activity toward NPZ sensing. In addition, under the optimized condition, the sensor demonstrates an acceptable linear range of 100 nM -15.6 μM, a lower limit of detection of 14 nM (S/N = 3), and higher sensitivity of 1.7484 μA μM-1 cm2. Furthermore, the proposed sensor has high selectivity, stability, reproducibility, and repeatability. Moreover, real sample analysis shows appreciable recovery results of 96 to 99% which strongly suggests that the proposed sensor has potential applicability for the sensitive detection of NPZ in the various water and biological samples.