화학공학소재연구정보센터
Polymer Bulletin, Vol.36, No.2, 221-225, 1996
Swelling Behavior of Temperature-Sensitive and pH-Sensitive Block Terpolymers for Drug-Delivery
Hydrogels prepared by block terpolymerization of N-isopropylacrylamide (NIPAAm), acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) exhibit significant temperature sensitivity due to the block structure of the NIPAAm moiety, even at concentrations as low as 10 mol%. pH-Sensitivity was also observed due to the ionizable AA component. The swelling ratio dependence on temperature is significantly more prominent for block terpolymers than for the corresponding random terpolymers.