The understanding of simple laminar flow in tubes has often been used to interpret the more complicated flow in porous media. A study of the motion of two immiscible liquids in closed tubes with relatively large diameter (> 0.3 cm i.d), was conducted in order to examine the influence of wetting and nonwetting liquids on the flow behavior. The results indicate that the wetting properties of the fluids with regard to the tube wall have a major efffect on the formation and motion of long bubbles. A physically based model was used to predict the velocity and the conditions for no motion of bubbles and drops in tubes. These results were used to interpret the nature of oil and water flow in porous media. Experiments in which the wetting liquid was displaced by the nonwetting, or vice versa, were conducted by injecting the displacing liquid at a constant flux at the center of a two-dimensional chamber saturated with the displaced liquid. The influence of wetting-nonwetting characteristics on the quantity of liquid displaced, the shape of the interface between the two liquids, and the interpretation of the no motion radius in a closed tube to the case of a porous medium are discussed. It would appear that the no motion radius gives a good indication of the minimum width of a nonwetting penetrating finger and the maximum width of nonwetting ganglia left by drainage.