Studies on the effect of calcination temperature, calcination time, concentration of HNO₃, boiling time and concentration of NaOH were conducted to manufacture GeO₂ from domestic germanium ore by new chemical process. In order to carry out this study, chemical analysis was performed. The results obtained were as followed; 1. The highest germanium content was leached out from the domestic germanium on condition that calcination temperature was 1,005 ℃, concentration of HNO₃ was 9N, boiling time was 4hr and concentration of NaOH was 50% 2. The manufactured product from the new chemical process was identified as GeO2 by X-ray diffraction analysis and infrared absorption spectra and its purity was 96.8 %.