Swelling Behavior and Mechanical Strength of Crosslinked Dextran Hydrogel

Byung-Hoon Kim; Doman Kim; Yong-Sik Jung; Hoon Kim; Dong Lyun Cho

Macromolecular Research, Vol.11, No.4, 291-295, August, 2003

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Swelling Behavior and Mechanical Strength of Crosslinked Dextran Hydrogel

Byung-Hoon Kim, Doman Kim, Yong-Sik Jung, Hoon Kim, and Dong Lyun Cho^†

Faculty of Applied Chemical Engineering and the Engineering Research Institute, Chonnam National University, Gwangju 500-757, Korea

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Dextran as a candidate material for colon-specific drug delivery has been studied. Crosslinked dextran hydrogels were prepared by mixing dextran, MgCl2, glutaraldehyde (GA) and polyethyleneglycol (PEG 400) in water. The dextran hydrogels were characterized by measuring equilibrium swelling ratios and mechanical strengths. Response surface methodology (Central Composite Design) was used to evaluate the swelling behaviors and mechanical strengths as functions of concentrations of MgCl2, GA, and PEG 400, which was found to be useful for the evaluation. It showed that the swelling behavior and mechanical strengths were influenced significantly by PEG 400 and MgCl2 concentrations.

Keywords:dextran;crosslinking;swelling;mechanical strength;response surface methodology

[References]

Chen J, Jo S, Park K, Carbohydrate Polym., 28, 69 (1995)
Hultin E, Nordstom L, Acta. Chem. Scand., 3, 1405 (1949)
Ingelman B, Acta. Chem. Scand., 2, 803 (1948)
Sery TW, Hehre EJ, J. Bacteriol., 71, 373 (1956)
Bailey RW, Clarke RTJ, Biochemistry, 72, 49 (1959)
Rosenfeld EL, Lukomskaya LS, Clin. Chim. Acta, 2, 105 (1957)
Segal A, The Clinical Use of Dextran Solution, Grune and Stratter, New York (1964)
deRaucort E, Mauray S, Chaubet F, Maiga-Revel O, Jozefowicz M, Fischer AM, J. Biomed. Mater. Res., 41, 49 (1998)
Hehre EJ, Sery TW, J. Bacteriol., 63, 424 (1952)
Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F, Anal. Chem., 28, 350 (1956)
McLeod AD, Friend DR, Tozer TN, J. Pharm. Sci., 83, 1284 (1994)
Brondsted H, Hovgaard L, Simonsen L, S.T.P. Pharm., 5, 60 (1995)
Brondsted H, Hovgaard L, Simonsen L, S.T.P. Pharm., 5, 65 (1995)
Brondsted H, Andersen C, Hovgaard L, J. Control. Release, 53, 7 (1998)
Ogata Y, Okano M, Ganke T, J. Am. Chem. Soc., 78, 2962 (1956)

[Referenced By]

[Related Articles]

[1] Chen J, Jo S, Park K, Carbohydrate Polym., 28, 69 (1995)

[2] Hultin E, Nordstom L, Acta. Chem. Scand., 3, 1405 (1949)

[3] Ingelman B, Acta. Chem. Scand., 2, 803 (1948)

[4] Sery TW, Hehre EJ, J. Bacteriol., 71, 373 (1956)

[5] Bailey RW, Clarke RTJ, Biochemistry, 72, 49 (1959)

[6] Rosenfeld EL, Lukomskaya LS, Clin. Chim. Acta, 2, 105 (1957)

[7] Segal A, The Clinical Use of Dextran Solution, Grune and Stratter, New York (1964)

[8] deRaucort E, Mauray S, Chaubet F, Maiga-Revel O, Jozefowicz M, Fischer AM, J. Biomed. Mater. Res., 41, 49 (1998)

[9] Hehre EJ, Sery TW, J. Bacteriol., 63, 424 (1952)

[10] Dubois M, Gilles KA, Hamilton JK, Rebers PA, Smith F, Anal. Chem., 28, 350 (1956)

[11] McLeod AD, Friend DR, Tozer TN, J. Pharm. Sci., 83, 1284 (1994)

[12] Brondsted H, Hovgaard L, Simonsen L, S.T.P. Pharm., 5, 60 (1995)

[13] Brondsted H, Hovgaard L, Simonsen L, S.T.P. Pharm., 5, 65 (1995)

[14] Brondsted H, Andersen C, Hovgaard L, J. Control. Release, 53, 7 (1998)

[15] Ogata Y, Okano M, Ganke T, J. Am. Chem. Soc., 78, 2962 (1956)