A procedure is presented for evaluating the shell side pressure drop in shell-and-tube heat exchangers with segmental baffles. The procedure is based on correlations for calculating the pressure drop in an ideal tube bank coupled with correction factors, which take into account the influence of leakage and bypass streams, and on equations for calculating the pressure drop in a window section from the Delaware method. The proposed equations were checked by comparing experimental measurements available in the literature with the theoretical predictions. The ranges of the geometrical and operational parameters, for which the deviations between the experimental measurements and the theoretical predictions were within +/- 35%, are presented in the paper.