Modeling of low-temperature ethane oxidation requires an accurate description of the reaction Of C2H5 + O-2, because its multiple reaction channels either accelerate the oxidation process via chain branching, or inhibit it by forming stable, less reactive products. We have used a steady-state chemical-activation analysis to generate pressure and temperature dependent rate coefficients for the various channels of this system. Input parameters for this analysis were obtained from ab initio calculations at the CBS-QB3 level of theory with bond-additivity corrections, followed by transition state theory calculations with Wigner tunneling corrections. The chemical-activation analysis used QRRK theory to determine k(E) and the modified strong collision (MSC) model to account for collisional deactivation. This procedure resulted in a C2H5 + O-2 submechanism which was either used directly (possibly augmented with a few C2H5 generating and consuming reactions) or as part of a larger extended mechanism to predict the temperature and pressure dependencies of the overall loss of ethyl and of the yields of ethylene, ethylene oxide, HO2, and OH. A comparison of the predictions using both mechanisms allowed an assessment of the sensitivity of the experimental data to secondary reactions. Except for the time dependent OH profiles, the predictions using the extended mechanism were in good agreement with the observations. By replacing the MSC model with master equation approaches, both steady-state and time dependent, it was confirmed that the MSC assumption is adequate for the analysis of the C2H5 + O-2 reaction. The good overall performance of the C2H5 + O-2 submechanism developed in this study suggests that it provides a good building block for an ethane oxidation mechanism.