Journal of Industrial and Engineering Chemistry, Vol.12, No.4, 643-647, July, 2006
Polymer-Supported Heterogeneous Chiral Ligands for Palladium- Catalyzed Asymmetric Allylic Alkylation
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Chiral thiophene derivatives prepared from enantiomerically pure (R,R)-1,2-diaminocyclohexane were successfully immobilized onto insoluble polymer support. The polymer-supported heterogeneous chiral ligands showed moderate reactivity and enantioselectivity (up to 71 %ee) in the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate, the enantioselectivity was maintained when the catalysts were recycled and reused two times without any radical loss.
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