A model-based predictive control methodology in the space of the latent variables for continuous processes is presented. Implementing identification and control in the latent variable space eases identification in the case of correlation in the data set, acts as a prefilter reducing the effect of noisy data, and reduces computational complexity. The proposed data-driven LV-MPC approach deals with setting the control horizon different to the prediction horizon, improves Hessian conditioning, and attains offset-free tracking. Additionally, a weighting matrix is introduced in the identification stage so that the performance of the predictor in the near horizon can be enhanced. A MIMO example shows how the proposed methodology can outperform conventional data-driven MPC in terms of computational complexity and reference tracking. (C) 2010 Elsevier Ltd. All rights reserved.