Journal of the American Chemical Society, Vol.132, No.16, 5564-5564, 2010
Inducing alpha-Helices in Short Oligopeptides through Binding by an Artificial Hydrophobic Cavity
Short peptides were induced into a-helix conformations in water through enclathration to an artificial hydrophobic cavity. Peptides with two aromatic residues showed high affinity for the host, and these intermolecular aromatic-aromatic interactions specifically drove the helical folding of short peptides.