전기분무에 의한 생분해성 폴리포스파젠 마이크로입자의 제조

Li-wei Xue; Qing Cai; 유승곤; Ri-guang Jin; Li-wei Xue; Qing Cai; Seung-Kon Ryu; Ri-guang Jin

Polymer(Korea), Vol.35, No.5, 424-430, September, 2011

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전기분무에 의한 생분해성 폴리포스파젠 마이크로입자의 제조

Fabrication of Biodegradable Polyphosphazene Microparticles by Electrohydrodynamic Atomization

Li-wei Xue, Qing Cai^†, 유승곤 ¹, Ri-guang Jin

Beijing University of Chemical Technology
¹충남대학교 화학공학과

Li-wei Xue, Qing Cai^†, Seung-Kon Ryu¹, and Ri-guang Jin

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China
¹Department of Chemical Engineering, Chungnam National University, Daejeon 305-764, Korea

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Biodegradable poly[(glycine ethyl ester)-(phenylalanine ethyl ester) phosphazene](PGPP) microparticles were fabricated by electrohydrodynamic atomization to apply drug release test. Atomization parameters such as applied voltage, polymer concentration, and molecular weight were investigated to inspect their effects on the size and morphology of microparticles. The average diameter of PGPP microparticles decreased as increasing applied voltage and solution flow rate. Dichloromethane/ dioxane mixture shows better results for the preparation of microparticles than single solvent owing to the different PGPP solubility in solvent. Blending PGPP polymers with proper molecular weights not only favored the production of spherical PGPP microparticles via electrohydrodynamic atomization, but also provided a way to adjust drug (rifampicin) release behavior. Drug-loaded biodegradable polyphosphazene microspheres can be fabricated via electrohydrodynamic atomization, which has potential use in biomedical applications.

Keywords:polyphosphazene;electrohydrodynamic atomization;microparticle.

[References]

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[2] Buchko CJ, Chen LC, Shen Y, Martin DC, Polymer, 40(26), 7397 (1999)

[3] Uematsu I, Matsumoto H, Morota K, Minagawa M, Tanioka A, Yamagata Y, Inoue K, J. Colloid Interface Sci., 269(2), 336 (2004)

[4] Jayasinghe SN, Edirisighe MJ, Zhang DZ, Nanotechnology., 15, 1519 (2004)

[5] Berkland C, Pack DW, Kim K, Biomaterials., 25, 5649 (2004)

[6] Loscertales IG, Barrero A, Guerrero I, Cortijo R, Marquez M, Ganan-Calvo AM, Science., 295, 1695 (2002)

[7] Ijsebaert JC, Geerse KB, Marijnissen JCM, Lammers JJ, Zanen P, J. Appl. Physiol., 91, 2735 (2001)

[8] Bugarski B, Li QL, Goosen MF, Poncelet D, Neufeld RJ, Vunjakg, AIChE J., 40(6), 1026 (1994)

[9] Ciach T, Int. J. Pharm., 324, 51 (2006)

[10] Geerse KB, Marijnissen JCM, Electrospray as Means to Produce Monodisperse Drug Particles, Grado′n L, Marijnissen JCM, Editors, Kluwer Academic Publishers, The Netherlands, pp 75-90 (2003)

[11] Hong SH, Moon JH, Lim JM, Kim SH, Yang SM, Langmuir, 21(23), 10416 (2005)

[12] Luna D, Timothy L, Chi-Hwa W, J. Control. Release., 102, 395 (2005)

[13] Jingwei X, Marijnissen JCM, Chi-Hwa W, Biomaterials., 27, 3321 (2006)

[14] Xie JW, Lim LK, Phua YY, Hua JS, Wang CH, J. Colloid Interface Sci., 302(1), 103 (2006)

[15] Jun Y, Kuang LL, Jing XW, Song HJ, Hwa WC, J. Aerosol Sci., 39, 987 (2008)

[16] Allcock HR, Chemistry and Applications of Polyphosphazenes, Wiley- Interscience, Hoboken, NJ. (2003)

[17] Lakshmi S, Katti DS, Laurencin CT, Adv. Drug Deliver. Rev., 55, 467 (2003)

[18] Laurencin CT, Koh HJ, Neenan TX, Allcock HR, Langer R, J. Biomed. Mater. Res., 21, 1231 (1987)

[19] Allcock HR, Pucher SR, Scepelianos AG, Biomaterials., 15, 563 (1994)

[20] Veronese FM, Marsilio F, Caliceti P, De Filippis P, Giunchedi P, Lora S, J. Control. Release., 52, 227 (1998)

[21] Veronese FM, Marsilio F, Lora S, Caliceti P, Passi P, Orsolini P, Biomaterials., 20, 91 (1999)

[22] Allcock HR, Fuller TJ, Mack DP, Matsumura K, Smeltz KM, Macromolecules., 10, 824 (1977)

[23] Allcock HR, Pucher SR, Scopelianos AG, Macromolecules, 27(5), 1071 (1994)

[24] Nishit D, Balabhaskar P, Angela RR, Kapil P, Shivshankar S, Samir M, J. Control. Release., 146, 196 (2010)

[25] Allcock HR, Fuller TJ, Mack DP, Matsumura K, Macromolecules., 10, 824 (1977)

[26] Allcock HR, Cook WJ, Mack DP, Inorg. Chem., 11, 2584 (1972)

[27] Zhang T, Cai Q, Polym. Mat. Sci. Eng., 22, 90 (2006)

[28] Qin QF, Dai YQ, Yi K, Zhang L, Ryu SK, Jin RG, Carbon Letters., 11, 176 (2010)

[29] Cheng RS, Polym. Commun., 4, 159 (1960)

[30] Yang JT, in Advances in Protein Chemistry, Academic Press, New York., 14, 323 (1961)

[31] Fong H, Chun I, Reneker DH, Polymer, 40(16), 4585 (1999)

[32] Lee KH, Kim HY, Bang HJ, Jung YH, Lee SG, Polymer, 44(14), 4029 (2003)

[33] McKee MG, Wilkes GL, Colby RH, Long TE, Macromolecules, 37(5), 1760 (2004)

[34] Son WK, Youk JH, Lee TS, Park WH, Polymer, 45(9), 2959 (2004)

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[36] Youliang H, Yanyan L, Yizi Y, Dongmei L, Guangtian Z, J. Aerosol Sci., 39, 525 (2008)