| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Zwitterionic sulfobetaine polymers grafted polyurethane surfaces through tyrosinase-mediated reaction for anti-calcification |
| 초록 |
A calcification has been major issue in the field of implantable device. This problem seriously has reduced their function and lifetime. In this study, the novel surface modification was developed for anti-calcification by immobilizing the anti-fouling zwitterionic polymers onto polyurethane (PU) surface. We synthesized phenol-conjugated zwitterionic poly(sulfobetaine methacrylate-co-tyramine) (pSBTA) and then grafted it onto PU surfaces via tyrosinase (Tyr)-catalyzed reaction. Which can immobilize the phenol moieties onto any kind of substrates in mild aqueous condition. The immobilization was confirmed by measuring water contact angle and XPS. The pSBTA grafted PU in vitro and in vivo significantly showed anti-calcification compared to bare PU as analyzed by SEM and ICP. These results suggest that surfaces modified with pSBTA via Tyr-catalyzed reaction could be promising candidates for an implantable medical device with calcification resistance. |
| 저자 |
김흥주1, 박경민2, 박기동1, 풍1
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| 소속 |
1아주대, 2인천대 |
| 키워드 |
surface modification; medical device; polymeric material
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| E-Mail |
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