Structure and biocompatibility of highly oriented poly(lactic acid) film produced by biaxial solid hot stretching

Zhengqiu Li; Lin Ye; Xiaowen Zhao; Phil Coates; Fin Caton-Rose; Michael Martyn

Journal of Industrial and Engineering Chemistry, Vol.52, 338-348, August, 2017

DOI10.1016/j.jiec.2017.04.008 Export Citation

Structure and biocompatibility of highly oriented poly(lactic acid) film produced by biaxial solid hot stretching

Zhengqiu Li, Lin Ye, Xiaowen Zhao^†, Phil Coates¹, Fin Caton-Rose¹, and Michael Martyn¹

State Key Laboratory of Polymer Materials Engineering of China, Polymer Research Institute of Sichuan University, Chengdu, China
¹School of Engineering, Design and Technology, University of Bradford, Bradford, UK

E-mail:

Highly oriented long-chain-branched poly(lactic acid) (LCB-PLA) film was fabricated through biaxial hot stretching in solid state. Compared with neat PLA, more homogeneous film with higher draw ratio can be obtained for LCB-PLA. With increasing draw ratio, the long period, lamellae thickness and grain size of LCB-PLA decreased, while the crystallinity increased. For LCB-PLA with draw ratio of 6*6, the tensile strength and elongation at break can reach up to 208 ± 6 MPa and 85% respectively. After drawing, the increasing content of -CH3 and C=O group on the surface of LCB-PLA film was beneficial for cell adhesion and growth on it.

Keywords:Poly(lactic acid) (PLA) film;Long chain branching;Biaxial orientation;Orientation structure;Biocompatibility

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[Referenced By]

[1] Sin LT, Rahmat AR, Rahman WAWA, Polylactic Acid: PLA Biopolymer Technology and Applications, Elsevier, Oxford, UK, 2012.

[2] Lasprilla AJR, Martinez GAR, Lunelli BH, Jardini AL, Filho RM, Biotechnol. Adv., 30, 321 (2012)

[3] Gandini A, Lacerda TM, Prog. Polym. Sci, 48, 1 (2015)

[4] Panyam J, Labhasetwar V, Adv. Drug Deliv. Rev., 55, 329 (2003)

[5] Woodruff MA, Hutmacher DW, Prog. Polym. Sci, 35, 1217 (2010)

[6] Paciotti GF, Myer L, Weinreich D, Goia D, Pavel N, McLaughlin RE, Tamarkin L, Drug Deliv., 11, 169 (2004)

[7] Lim LT, Auras R, Rubino M, Prog. Polym. Sci, 33, 820 (2008)

[8] Ward IM, Sweeney J, Mechanical Properties of Solid Polymers, Wiley, Chichester, New York, 1983.

[9] Ghazaryan G, Schaller R, Feldman K, Tervoort TA, J. Polym. Sci. B: Polym. Phys., 54(21), 2233 (2016)

[10] Robertson GL, Food Packaging: Principles and Practice, Blackwell Publishing Ltd, Oxford, UK, 2003.

[11] Yu L, Liu HS, Xie FW, Chen L, Li XX, Polym. Eng. Sci., 48(4), 634 (2008)

[12] Tsai CC, Wu RJ, Cheng HY, Polym. Degrad. Stabil., 95, 1292 (2010)

[13] Jariyasakoolroj P, Tashiro K, Wang H, Yamamoto H, Chinsirikul W, Kerddonfag N, Chirachanchai S, Polymer, 68, 234 (2015)

[14] Arnold JC, Dves OM, Yield Fract. Polym. (1997) 298.

[15] Ou X, Cakmak M, Polymer, 49(24), 5344 (2008)

[16] Li ZQ, Zhao XW, Ye L, Coates P, Caton-Rose F, Martyn M, Chem. Eng. J., 279, 767 (2015)

[17] Li ZQ, Zhao XW, Ye L, Coates P, Caton-Rose F, Martyn M, Polymer, 56, 523 (2015)

[18] Li Z, Zhao X, Ye L, J. Biomed. Mater. Res., 5, 1082 (2016)

[19] Liu X, Dever M, Fair N, Benson RS, J. Environ. Polym. Degrad., 5, 225 (1997)

[20] Najafi N, Heuzey MC, Carreau PJ, Polym. Degrad. Stabil., 97, 554 (2012)

[21] Lehermeier HJ, Dorgan JR, Polym. Eng. Sci., 41(12), 2172 (2001)

[22] Cailloux J, Perez OOS, Urquiza EAF, eXPRESS Polym. Lett., 3, 304 (2013)

[23] Gupta RK, Polymer and Composite Rheology, CRC Press, 2000.

[24] Cogswell FN, Trans. Soc. Rheol., 16, 383 (1972)

[25] Tadmor Z, Gogos CG, Principles of Polymer Processing, John Wiley & Sons, 2013.

[26] Khodabakhshi K, Ehsani M, Development and applications of sustainable polylactic acid parts, Handbook of Sustainable Polymers: Processing and Applications, Pan Stanford Publishing Pte. Lte, Singapore, 2016, pp. 397.

[27] Liu JY, Lou LJ, Yu W, Liao RG, Li RM, Zhou CX, Polymer, 51(22), 5186 (2010)

[28] Marubayashi H, Asai S, Sumita M, Macromolecules, 45(3), 1384 (2012)

[29] Zhang CM, Zhai TL, Turng LS, Dan Y, Ind. Eng. Chem. Res., 54(38), 9505 (2015)

[30] Ertel SI, Chilkoti A, Horbetti TA, Ratner B, J. Biomater. Sci.-Polym. Ed., 2, 163 (2012)

[31] Meaurio E, de Arenaza IM, Lizundia E, Sarasua JR, Macromolecules, 42(15), 5717 (2009)

[32] Lampin M, Waropuier-Clerout LC, Degrange M, Sigot-Luizard MF, J. Biomed. Mater. Res., 36, 99 (1997)