Development of Ca-alginate-chitosan microcapsules for encapsulation and controlled release of imidacloprid to control dengue outbreaks

Gim-Pao Lim; Muhammad Syarhabil Ahmad

Journal of Industrial and Engineering Chemistry, Vol.56, 382-393, December, 2017

DOI10.1016/j.jiec.2017.07.035 Export Citation

Development of Ca-alginate-chitosan microcapsules for encapsulation and controlled release of imidacloprid to control dengue outbreaks

Gim-Pao Lim^†, and Muhammad Syarhabil Ahmad

School of Bioprocess Engineering, Universiti Malaysia Perlis, Kompleks Pusat Pengajian Jejawi 3, 02600 Arau, Perlis, Malaysia

E-mail:

Ca-alginate-chitosan based microcapsules were prepared and used for the controlled release of imidacloprid larvacide against Aedes aegypti larvae. Imidacloprid encapsulation was evidenced through HPLC and FTIR analysis. Imidacloprid loading varied from 2.79% to 6.85% with encapsulation efficiency of up to 39.16%. TGA and DSC studies revealed good thermal stability and compatibility between the polymers and imidacloprid. X-ray diffractometry (XRD) results indicated a molecular level dispersion of imidacloprid in the polymer matrix. The in vitro release profiles of imidacloprid could be controlled by modifying the formulation, pH, or temperature. The imidacloprid release kinetics fit the Korsmeyer. Peppas model and follows the anomalous transport profile. The mechanism of imidacloprid release was proposed. In vivo release studies demonstrated that a dose of 6.11 mg/L is sufficient to destroy Aedes aegypti larvae. It was predicted that 50% and 100% larvae mortality are achieved for 369 and 141 days respectively.

Keywords:Larvacide;Chitosan;Alginate;Encapsulation;Sustained release

[References]

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[Referenced By]

[1] Becker N, J. Am. Mosq. Control Assoc., 19, 63 (2003)

[2] Gubler DJ, Kuno G, Markoff L, Fields Virology, 5th edition, Lippincott-Raven Publishers, Philadelphia, PA, USA, p. 1497 2007.

[3] http://www.thestar.com.my/news/nation/2016/01/06/50-rise-in-dengue-deaths-health-ministry-upward-trend-also-observed-in-other-countries/.

[4] Paula HCB, Oliveira EFD, Abreu FOMS, Paula RCM, Mater. Sci. Eng. A-Struct. Mater. Prop. Microstruct. Process., 32, 1421 (2012)

[5] Elbert A, Haas M, Springer B, Thielert W, Nauen R, Pest Manage. Sci., 64, 1099 (2008)

[6] Bhan S, Mohan L, Srivastava CN, J. Asia Pac. Entomol., 17(4), 787 (2014)

[7] Yi Y, Xu S, Sun H, Carbohydr. Polym., 86(2), 1007 (2011)

[8] Pradas EG, Perez MF, Sanchez MV, Cespedes FF, Pestic. Sci., 1109 (1999).

[9] Monteiro LCC, Souza JRB, Albuquerque CMR, Neotrop. Entomol., 36, 966 (2007)

[10] Kimura IY, Goncalves AC, Stolberg J, Laranjeira MCM, Favere VT, Polimeros, 9(2), 51 (1999)

[11] Tian J, Xu SS, Deng HB, Song XX, Song XX, Li ZJ, Chen JJ, Cao F, Bin L, Int. J. Pharm., 517(1), 25 (2017)

[12] Li S, Xiao L, Deng HB, Shi XW, Cao QH, Colloids Surf. B: Biointerfaces, 151, 354 (2017)

[13] Zhao QS, Ji QX, Cheng XJ, Sun GZ, Ran C, Zhao B, Chen XG, J. Sol-Gel Sci. Technol., 54, 232 (2010)

[14] Khan MS, Sridhar BK, Srinatha A, Indian J. Pharm. Sci., 72(1), 18 (2010)

[15] Ding FY, Wu SP, Wang SH, Xiong Y, Li Y, Li B, Deng HB, Du YM, Xiao L, Shi XW, Soft Matter, 20(11), 3971 (2015)

[16] Liu B, Luo JW, Wang XY, Lu JX, Deng HB, Sun RC, J. Biomater. Sci.-Polym. Ed., 24(5), 589 (2013)

[17] Zhang S, Chen J, Yin XQ, Wang XY, Qiu BN, Zhu L, Lin Q, J. Appl. Polym. Sci., 134, 44662 (2016)

[18] Vincekovic M, Jelsenjak N, Pintaric ST, Dermic E, Bujan M, Juric S, Agric J, Food Chem., 64(43), 8073 (2016)

[19] Ren ZY, Zhang XR, Guo Y, Han KG, Huo N, Food Agric. Immunol., 28(1), 1 (2017)

[20] Blandino A, Macias M, Cantero D, Enzyme Microb. Technol., 27(3-5), 319 (2000)

[21] Kourkoutas Y, Bekatorou A, Banatb IM, Marchant R, Koutinas AA, Food Microbiol., 2, 377 (2004)

[22] Abang S, Chan ES, Poncelet D, J. Microencapsul., 29(5), 417 (2012)

[23] Flores CF, Isabel FFC, Daza FI, Vidal PF, Villa franca SM, Ferna’ndez PM, J. Agric. Food Chem., 60, 1042 (2012)

[24] Alba ARF, Valverde A, Aguera A, Contreras M, Chiron S, J. Chromatogr. A, 721, 97 (1996)

[25] Ritger P, Peppas NA, J. Control. Release, 5, 37 (1987)

[26] Agostini DMM, Sgarbi CD, Cruz VFD, Fernandes FL, Masumi BM, J. Environ. Manage., 131, 222 (2013)

[27] Meng X, Tian F, Yang J, He CN, Xing N, Li F, J. Mater. Sci. -Mater. Med., 21, 1751 (2010)

[28] Eldin M, Omer AM, Wassel MA, Tamer TM, Elmonem ABD, Ibrahim SA, J. Pharm. Pharm. Sci., 10, 331 (2015)

[29] Roy A, Bajpai J, Bajpai AK, Carbohydr. Polym., 76, 222 (2009)

[30] Liu Y, Zhao JC, Zhang CJ, Guo Y, Cui L, Zhu P, Wang DY, RSC Adv., 5(64), 125 (2015)

[31] Liang R, Liu M, J. Agric. Food Chem., 54, 1392 (2006)

[32] Mo F, Lin BF, Lai FJ, Xu CH, Zou HZ, Ind. Eng. Chem. Res., 55(16), 4490 (2016)

[33] Davidenko N, Carrodeguas RG, Peniche C, Sol’ıs Y, Cameron RE, Acta Biomater., 6(2), 466 (2010)

[34] Phugare SS, Kalyani DD, Gaikwad YB, Jadhav JP, Chem. Eng. Sci., 230, 27 (2013)

[35] Ribeiro AJ, Silva C, Ferreira D, Veiga F, J. Eur, Pharm. Sci, 25(1), 31 (2005)

[36] Lakouraj MM, Mojerlou F, Zare EN, Carbohydr. Polym., 106, 34 (2014)

[37] Takka S, Ocak OH, Acarturk F, Eur. J. Pharm. Sci., 6, 241 (1998)

[38] Siepmann J, Peppas NA, Adv. Drug Deliv. Rev., 48, 138 (2001)

[39] Liang R, Liu M, Agric J, Food Chem., 54, 1392 (2006)

[40] Azeem B, Shaari KK, Man ZB, Basit A, Thanh THJ, Control. Release, 181, 11 (2014)

[41] Paula HCB, de Paula RCM, Bezerral SKF, J. Appl. Polym. Sci., 102(1), 395 (2006)