관상동맥질환 치료를 위한 생체흡수형스텐트의 개발 동향

정경원; 김태훈; 나재운; 박준규; Gyeong-Won Jeong; Tae-Hoon Kim; Jae-Woon Nah; Jun-Kyu Park

Applied Chemistry for Engineering, Vol.29, No.5, 497-502, October, 2018

DOI10.14478/ace.2018.1085 Export Citation

관상동맥질환 치료를 위한 생체흡수형스텐트의 개발 동향

The Developing Trend in Bioresorbable Stent for Treatment of Coronary Artery Disease

정경원, 김태훈¹, 나재운^†, 박준규^{1, †}

순천대학교 공과대학 고분자공학과
¹(주)시지바이오

Gyeong-Won Jeong, Tae-Hoon Kim¹, Jae-Woon Nah^†, and Jun-Kyu Park^{1, †}

Department of Polymer Science and Engineering, Sunchon National University, Jeonnam 57922, Republic of Korea
¹CGbio Co.Ltd, Jeonnam Jangseong-gun 58275, Republic of Korea

E-mail:,

초록

협심증, 심근경색과 같은 관상동맥 질환은 급속도로 증가하고 있다. 관상동맥 질환은 콜레스테롤과 칼슘과 같은 플라크들이 혈관벽에 흡착되어 발생한다. 심혈관 중재시술은 풍선 카테터와 금속스텐트를 이용하여 좁아진 관상동맥혈관을 확장시키는 비수술적 시술방법이다. 금속재질의 스텐트는 관상동맥질환에 의한 사망자를 감소시키는데 효과적이 었지만 영구적으로 혈관에 금속재질 스텐트가 이식되어 있기 때문에 지속적인 염증과 후기 혈전증 등이 발생되었다. 따라서, 스텐트와 같은 영구적 보철물에 의한 합병증과 재협착 등을 해결하기 위한 생체 흡수성 혈관 지지체의 개발은 급속도로 증가되고 있다. 이 리뷰에서는 생체흡수형스텐트의 성공적인 개발을 위한 동향에 대해서 논하고자 한다.

The coronary artery disease (CAD) is rapidly increasing such as angina pectoris and atherosclerosis. The CAD is induce by cholesterol and calcium like plaque absortion to artery wall. The percutaneouss coronary intervention is non-invasive treatment that narrowed-artery is expand by using balloon catheter and bare metallic stent. The metallic stents have been effective in reducing the dead by coronary artery disease, but the permanent presence of the metallic stent has been associated with persistent inflammation, and incidence of late thrombosis. Therefore, development bioresorbable vascular scaffold (BRS) is rapidly increasing for treatment of long-term complications and arterial restenosis by permanentmetal prosthesis such as stent. The review discusses the BRS trend for successfully development.

Keywords:coronary stent;coroanry artery disease;bioresorbable stent;intervention

[References]

Landau C, Lange RA, Hilis LD, N. Engl. J. Med., 330, 981 (1994)
Buchanan GL, Basavarajaiah S, Chieffo A, Thrombosis, 2012, 956 (2012)
Gogas BD, Glob. Cardiol. Sci. Pract., 40, 409 (2014)
Abizaid A, Costa RA, Schofer J, J. Am. Coll. Cardiol., 9, 565 (2016)
Verheye S, Ormiston JA, Stewart J, Webster M, Sanidas E, Costa R, JACC Cardiovasc. Interv., 7, 89 (2014)
Ying M, Chunjiao Z, Gloval Bioresorbable Vascular Scaffold Sales Market Report 2017, 1-129, QYResearch, CA, USA (2017).
Lee YC, Health Industry Brief Medical Device Market Statistics: Stent, Korea Health Industry Development Institute, 52, 1-20 (2017).
Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang Y, Foin N, Int. J. Cardiol., 228, 931 (2017)
Hermawan H, Dube D, Mantovani D, Acta Biomater, 6, 1693 (2010)
Iqbal J, Ounuma Y, Ormistion J, Abizaid A, Wasksman R, Serruys PW, Eur. Heart J., 35, 765 (2014)
Tenekecioglu E, Serruys PW, Onuma Y, Costa R, Chamie D, Sotomi Y, Yu TB, Abizaid A, Liew HB, Santoso T, JACC Cadiovasc. Interv., 10(11), 1115 (2010)
Chen MC, Chang Y, Liu CT, Lai WY, Peng SF, Hung YW, Tasi HW, Sung H, Biomaterials, 30, 79 (2009)
Park SA, Lee SJ, Lim KS, Bae IH, Lee JH, Kim WD, Jeong MH, Park JK, Mater. Lett., 141, 355 (2015)
Gogas B, Farooq V, Onuma Y, Serruys PW, Hellenic J. Cardiol., 53, 301 (2012)
Serruys PW, Onuma Y, Garcia HM, Muramatsu T, et al., Eurointervention, 9(11), 1271 (2014)
Staehr P, 17th Asian Harmonization Working Party Annual Conference, November 2-6, Taipei, Taiwan (2012).
Regazzoli D, Leone P, Colombo A, Latib A, J. Thorac. Dis., 9, 979 (2017)
McMahon S, Bertolo N, O’Cearbhaill ED, Salber J, Pierucci L, Duffy P, Durig T, Bi V, Wang W, Prog. Polym. Sci, 83, 79 (2018)
Abizaid A, Carrie D, Frey N, Lutz M, Weber-Albers J, Dudek D, JACC Cadiovac. Interv., 10, 1832 (2017)
Schmidt W, Behrens P, Brandt-Wunderlich C, Siewert S, Grabow N, Schmitz KP, Cardiovasc. Revasc. Med., 17, 375 (2016)
Campos C, Zhanh Y, Boutantas C, Muramatsu T, Garcia H, Lemos P, Onuma Y, Serruys PW, J. Interv. Cardiol., 5, 639 (2013)
Abizaid A, presented in EuroPCR 2013, May 21, Paris, France (2013).
Gogas BD, Glob. Cardiol. Sci. Pract., 40, 409 (2014)
Vahl TP, Gasior P, Gongora CA, Ramzipoor K, Lee C, Cheong Y, Eurointervention, 12, 1510 (2016)
Rao AS, Makaroun MS, Marone LK, Cho JS, Rhee R, Chaer RA, Stroke, 40, 499 (2009)
Seth A, Onuma Y, Costa R, Chandra P, Bahl VK, Manjunath CN, Eurointervention, 13, 415 (2017)
Wu Y, Shen L, Wang Q, Ge L, Xie J, Hu X, J. Biomed. Biotechnol., 2012, 1 (2012)
Zhang Y, Bourantas CV, Farooq V, Muramastsu T, Diletti R, Onuma Y, Garcia HM, Serruys PW, Med. Devices, 6, 37 (2013)
Rapetto C, Leoncini M, J. Thorac. Dis., 9, S903 (2017)

[1] Landau C, Lange RA, Hilis LD, N. Engl. J. Med., 330, 981 (1994)

[2] Buchanan GL, Basavarajaiah S, Chieffo A, Thrombosis, 2012, 956 (2012)

[3] Gogas BD, Glob. Cardiol. Sci. Pract., 40, 409 (2014)

[4] Abizaid A, Costa RA, Schofer J, J. Am. Coll. Cardiol., 9, 565 (2016)

[5] Verheye S, Ormiston JA, Stewart J, Webster M, Sanidas E, Costa R, JACC Cardiovasc. Interv., 7, 89 (2014)

[6] Ying M, Chunjiao Z, Gloval Bioresorbable Vascular Scaffold Sales Market Report 2017, 1-129, QYResearch, CA, USA (2017).

[7] Lee YC, Health Industry Brief Medical Device Market Statistics: Stent, Korea Health Industry Development Institute, 52, 1-20 (2017).

[8] Ang HY, Bulluck H, Wong P, Venkatraman SS, Huang Y, Foin N, Int. J. Cardiol., 228, 931 (2017)

[9] Hermawan H, Dube D, Mantovani D, Acta Biomater, 6, 1693 (2010)

[10] Iqbal J, Ounuma Y, Ormistion J, Abizaid A, Wasksman R, Serruys PW, Eur. Heart J., 35, 765 (2014)

[11] Tenekecioglu E, Serruys PW, Onuma Y, Costa R, Chamie D, Sotomi Y, Yu TB, Abizaid A, Liew HB, Santoso T, JACC Cadiovasc. Interv., 10(11), 1115 (2010)

[12] Chen MC, Chang Y, Liu CT, Lai WY, Peng SF, Hung YW, Tasi HW, Sung H, Biomaterials, 30, 79 (2009)

[13] Park SA, Lee SJ, Lim KS, Bae IH, Lee JH, Kim WD, Jeong MH, Park JK, Mater. Lett., 141, 355 (2015)

[14] Gogas B, Farooq V, Onuma Y, Serruys PW, Hellenic J. Cardiol., 53, 301 (2012)

[15] Serruys PW, Onuma Y, Garcia HM, Muramatsu T, et al., Eurointervention, 9(11), 1271 (2014)

[16] Staehr P, 17th Asian Harmonization Working Party Annual Conference, November 2-6, Taipei, Taiwan (2012).

[17] Regazzoli D, Leone P, Colombo A, Latib A, J. Thorac. Dis., 9, 979 (2017)

[18] McMahon S, Bertolo N, O’Cearbhaill ED, Salber J, Pierucci L, Duffy P, Durig T, Bi V, Wang W, Prog. Polym. Sci, 83, 79 (2018)

[19] Abizaid A, Carrie D, Frey N, Lutz M, Weber-Albers J, Dudek D, JACC Cadiovac. Interv., 10, 1832 (2017)

[20] Schmidt W, Behrens P, Brandt-Wunderlich C, Siewert S, Grabow N, Schmitz KP, Cardiovasc. Revasc. Med., 17, 375 (2016)

[21] Campos C, Zhanh Y, Boutantas C, Muramatsu T, Garcia H, Lemos P, Onuma Y, Serruys PW, J. Interv. Cardiol., 5, 639 (2013)

[22] Abizaid A, presented in EuroPCR 2013, May 21, Paris, France (2013).

[23] Gogas BD, Glob. Cardiol. Sci. Pract., 40, 409 (2014)

[24] Vahl TP, Gasior P, Gongora CA, Ramzipoor K, Lee C, Cheong Y, Eurointervention, 12, 1510 (2016)

[25] Rao AS, Makaroun MS, Marone LK, Cho JS, Rhee R, Chaer RA, Stroke, 40, 499 (2009)

[26] Seth A, Onuma Y, Costa R, Chandra P, Bahl VK, Manjunath CN, Eurointervention, 13, 415 (2017)

[27] Wu Y, Shen L, Wang Q, Ge L, Xie J, Hu X, J. Biomed. Biotechnol., 2012, 1 (2012)

[28] Zhang Y, Bourantas CV, Farooq V, Muramastsu T, Diletti R, Onuma Y, Garcia HM, Serruys PW, Med. Devices, 6, 37 (2013)

[29] Rapetto C, Leoncini M, J. Thorac. Dis., 9, S903 (2017)