화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.27, No.11, 1144-1154, November, 2019
DOI10.1007/s13233-019-7152-y  Export Citation
PVA Hydrogel Functionalization via PET-RAFT Grafting with Glycidyl Methacrylate and Immobilization with 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan via Ring-Open Reaction
Jinsheng Zhou1, †, Yanming Lin2, Lin Ye3, 4, Ling Wang3, 4, Li Zhou2, Huiyuan Hu2, Qilong Zhang1, Hui Yang1, and Zhongkuan Luo1, 2, †
  • 1School of Material Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China
  • 2College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, Guangdong, P. R. China
  • 3Shenzhen Eye Hospital, Shenzhen 518000, Guangdong, P. R. China
  • 4Shenzhen Key Laboratory of Ophthalmology, Shenzhen 518000, Guangdong, P. R. China
E-mail:,
To solve the biofouling problem of polyvinyl alcohol (PVA) hydrogel as the artificial cornea, glycidyl methacrylate (GMA) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were grafted on the surface of PVA hydrogel via a new method of photoinduced electron transfer?reversible addition fragmentation chain transfer (PET-RAFT) polymerization and ring-open reaction. Both attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), scanning electron microscope (SEM), and thermogravimetric analysis (TGA) confirmed that GMA and HACC were successfully grafted on the surface of PVA hydrogel. A series of experiments to test the hydrophilicity of PVA hydrogel showed that it became hydrophobic due to the introduction of hydrophobic groups after grafting with GMA and HACC. In addition, cytotoxicity in vitro of PVA-g-p(GMA-HACC) hydrogel could be considered as not cytotoxicity according to ISO 10993-5: 2009. The anti-fouling property of hydrogel decreased after grafting with GMA due to the hydrophobic surface, while increased after grafting with HACC due to the steric repulsion of p(GMA-HACC) polymer brush. It’s no doubt that PET-RAFT was a feasible and reliable surface modification method which could be used in many biomolecules due to the excellent advantages.
Keywords:polyvinyl alcohol (PVA) hydrogel;glycidyl methacrylate (GMA);2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC);photoinduced electron transfer.reversible addition fragmentation chain transfer (PET-RAFT);surface modification
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