화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.98, 211-216, June, 2021
DOI10.1016/j.jiec.2021.03.052  Export Citation
Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy
Yoon Ho Roh, Ji Yeon Eom, Dae Gun Choi1, Ju Yeon Moon, Min Suk Shim1, †, and Ki Wan Bong†
  • Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea
  • 1Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea
E-mail:,
Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) micro- particles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX- GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR lighttriggered drug release.
Keywords:Poly(N-vinyl caprolactam);Gold nanorod;Stop-flow lithography;NIR light;Photothermal effect;Cancer therapy
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