화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.38, No.8, 1669-1675, August, 2021
DOI10.1007/s11814-021-0807-3  Export Citation
Optimization of preparation and properties of Gardenia yellow pigment-loaded alginate beads
Yong Liu1, †, Qing Zhou1, 2, Yan-Mei He1, Xiu-Yun Ma1, Lin-Na Liu1, and Yong-Jian Ke1
  • 1School of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, China
  • 2School of Light Industry and Chemical Engineering, Guangdong University of Technology, Guangzhou, China
E-mail:
Gardenia yellow pigment (GYP) loaded alginate beads were prepared by the ionic gelation technique, and the preparation parameters were optimized by response surface methodology for high encapsulation efficiency. The optimized parameters were alginate concentration of 3.3%, CaCl2 concentration of 2.4%, and GYP concentration of 3.2mg/mL, under which the encapsulation efficiency was 73.61%. The surface morphology and bead size analysis showed that the GYP-loaded alginate beads had a roughly spherical morphology with a wrinkled surface, and their average diameter was 0.87 mm. In vitro release test revealed that the GYP release had a pH-dependent release profile and a two-step release process. The Rigter-Peppas model was the most proper model to assess the GYP release from alginate beads. The release mechanism of GYP at pH 1.2 and 7.4 was non-Fickian transport and case-II transport, respectively. The 2,2-diphenyl-1-picrylhydrazyl assay indicated that the encapsulated GYP had effectively maintained 82.56% of the antioxidant activity.
Keywords:Sodium Alginate;Response Surface Methodology;Release Kinetics;Antioxidant Activity;Pigment
  1. Chen L, Li M, Yang Z, Tao W, Wang P, Tian X, Li X, Wang W, J. Ethnopharmacol., 257, 112829 (2020)
  2. Okoshi K, Uekusa Y, Narukawa Y, Kiuchi F, J. Nat. Med., 75, 76 (2021)
  3. Li HB, Ma JF, Mei YD, Liu LX, Cao ZY, Shi DF, Yao XS, Yu Y, Nat. Prod. Res. (2020), https://doi.org/10.1080/14786419.2020.1775227.
  4. Zhang N, Luo M, He L, Yao L, Molecules, 25, 4702 (2020)
  5. Chen Q, Xue G, Ni Q, Wang Y, Gao Q, Zhang Y, Xu G, Food Sci. Nutr., 8, 1 (2020)
  6. Wu J, Zhang J, Yu X, Shu Y, Zhang S, Zhang Y, Food Sci. Nutr., 9, 822 (2021)
  7. Xu W, Yu J, Feng W, Su W, Molecules, 21, 540 (2016)
  8. Xiao W, Li S, Wang S, Ho CT, J. Food Drug Anal., 25, 43 (2017)
  9. Juric S, et al., Food Rev. Int. (2020), https://doi.org/10.1080/87559129.2020.1837862.
  10. Utpott M, Assis RQ, Pagno CH, Krigger SP, Rodrigues E, Rios ADO, Flores SH, Food Bioprocess Technol., 13, 1940 (2020)
  11. Otalora MC, Carriazo JG, Iturriaga L, Osorio C, Nazareno MA, Food Chem., 202, 373 (2016)
  12. Rubio FTV, Haminiuk CWI, Martelli-Tosi M, Silva MPD, Makimori GYF, Favaro-Trindade CS, Food Res. Int., 136, 109470 (2020)
  13. Li Y, Tang B, Chen J, Lai P, Food Sci. Technol., 38, 530 (2018)
  14. Cortez R, Luna-Vital DA, Margulis D, Mejia EGD, Compr. Rev. Food Sci. Food Saf., 16, 180 (2017)
  15. Siang SC, Wai LK, Lin NK, Phing PL, Food Sci. Technol., 39, 601 (2019)
  16. Arriola NDA, Chater PI, Wilcox M, Lucini L, Rocchetti G, Dalmina M, Pearson JP, Amboni RDDMC, Food Chem., 275, 123 (2019)
  17. Vasile FE, Judis MA, Mazzobre MF, Food Chem., 250, 75 (2018)
  18. Otalora MC, Carriazo JG, Osorio C, Nazareno MA, Food Res. Int., 111, 423 (2018)
  19. Liu G, Hu Z, Guan R, Zhao Y, Zhang H, Zhang B, Korean J. Chem. Eng., 33(11), 3141 (2016)
  20. Cho SV, Kang JW, Lee JH, Korean J. Chem. Eng., 37(10), 1726 (2020)
  21. Orozco-Villafuerte J, Escobar-Rojas A, Buendia-Gonzalez L, Garcia-Morales C, Hernandez-Jaimes C, Alvarez-Ramirez A, J. Dispersion Sci. Technol., 40, 1065 (2019)
  22. Gallo TCB, Cattelan MG, Alvim ID, Nicoletti VR, J. Food Process. Preserv., 44, e14947 (2020)
  23. Gholamian S, Nourani M, Bakhshi N, Food Chem., 338, 128143 (2021)
  24. Calvo TRA, Perullini M, Santagapita PR, J. Food Eng., 235, 32 (2018)
  25. Niizawa I, Espinaco BY, Zorrilla SE, Sihufe GA, Int. J. Biol. Macromol., 121, 601 (2019)
  26. Carvalho AGD, Machado MTD, Barros HDDQ, Cazarin CBB, Marostica MR, Hubinger MD, Powder Technol., 345, 283 (2019)
  27. Liu Y, Li CY, Huang HM, Peng HH, Shen MY, Hu XH, Food Industry, 38, 84 (2017)
  28. Zhu X, Mang Y, Shen F, Xie J, Su W, J. Food Sci. Technol., 51, 1575 (2014)
  29. Liu Y, Wei S, Liao M, Ind. Crop. Prod., 49, 837 (2013)
  30. Gu L, McClements DJ, Li J, Su Y, Yang Y, Li J, Food Hydrocolloids, 112, 106349 (2021)
  31. Peppas NA, Sahlin JJ, Int. J. Pharmaceut., 57, 169 (1989)
  32. Gombotz WR, Wee SF, Adv. Drug Deliv. Rev., 64, 194 (2012)
  33. Rousseau I, Cerf DL, Picton L, Argillier JF, Muller G, Eur. Polym. J., 40, 2709 (2004)
  34. Hills BP, Godward J, Debatty M, Barras L, Saturio CP, Ouwerx C, Magn. Reson. Chem., 38, 719 (2000)
  35. Bilal M, Iqbal HMN, Biocatal. Agric. Biotechnol., 20, 101205 (2019)
  36. Zhang J, Li HH, Chen YF, Chen LH, Tang HG, Kong FB, Yao YX, Liu XM, Lan Q, Yu XF, J. Zhejiang Univ. Sci. B, 21, 611 (2020)
  37. Benfattoum K, Haddadine N, Bouslah N, Benaboura A, Maincent P, Barille R, Sapin-Minet A, El-Shall MS, Polym. Adv. Technol., 29, 884 (2018)
  38. Celli GB, Ghanem A, Brooks MSL, J. Berry Res., 6, 1 (2016)
  39. Jiang ZY, Zhang YF, Li J, Jiang W, Yang D, Wu H, Ind. Eng. Chem. Res., 46(7), 1883 (2007)
  40. Tu QB, Wang PY, Shen S, Xu Y, Wang JZ, You S, Zhu AH, Wang J, Wu FA, Waste Biomass Valor., 11, 5273 (2020)
  41. Chen M, Hu Y, Zhou J, Xie Y, Wu H, Yuan T, Yang Z, RSC Adv., 16, 13032 (2016)
  42. Liu Y, Wei S, Liu L, Liao M, Huang Y, RSC Adv., 5, 5533 (2015)
  43. Zhou M, Hu Q, Wang T, Xue J, Luo Y, Int. J. Biol. Macromol., 120, 859 (2018)
  44. Li Q, Duan M, Hou D, Chen X, Shi J, Zhou W, Food Hydrocolloids, 112, 106274 (2021)
  45. Busic A, Belscak-Cvitanovic A, Cebina AV, Karlovic S, Kovac V, Spoljaric I, Mrsic G, Komes D, Food Res. Int., 111, 244 (2018)
  46. Belscak-Cvitanovic A, Komesa D, Karlovic S, Djakovic S, Spoljaric I, Mrsic G, Jezek D, Food Chem., 167, 378 (2015)
  47. Essifi K, et al., Polym. Bull. (2020), https://doi.org/10.1007/s00289-020-03397-9.
  48. Olayemi OJ, Apeji YE, Isimi CY, J. Pharm. Innov. (2020), https://doi.org/10.1007/s12247-020-09509-2.
  49. Yin ZC, Wang YL, Wang K, J. Drug Deliv. Sci. Technol., 43, 12 (2018)
  50. Sun X, Liu C, Omer AM, Yang LY, Ouyang XK, Int. J. Biol. Macromol., 132, 487 (2019)
  51. Kim H, Fassihi R, Pharm. Res., 14, 1415 (1997)