The clathrate formation of a crystalline host with acetone and methanol vapours has been studied by means of simultaneous TG-DSC measurements in isothermal and scanning mode of operation. The directly measured enthalpies of inclusion at 25 degrees C for acetone (-47.8 kJ mol(-1)) and methanol (-48.6 kJ mol(-1)) are significantly higher than known thermal desorption enthalpy data from DSC measurements. Concentration dependent measurements indicate a nearly linear concentration dependence for both the amount of guest included and the heat effect over a wide range supporting the recently suggested importance of this class of supramolecular hosts as chemical sensitive coating materials for sensor applications. Inclusion experiments at different temperatures indicate a strongly decreasing inclusion ability with increasing temperature.