Nanoemulsion as a Vitamin E Acetate Carrier to Enhance Infiltration into Oral Mucous Membrane

Hyung Seok Kang; Sun-Sang Kwon; Bae-Hwan Kim; Byung-Reul Lee; Kye-Hong Kang; Jong-Eoun Hong; Sang-Hoon Han; Ih-Seop Chang

Journal of Industrial and Engineering Chemistry, Vol.8, No.4, 348-353, July, 2002

Hyung Seok Kang^†, Sun-Sang Kwon, Bae-Hwan Kim, Byung-Reul Lee, Kye-Hong Kang, Jong-Eoun Hong, Sang-Hoon Han, and Ih-Seop Chang

Amore Pacific R&D Center, Kyounggi-do 449-729, Korea

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The infiltration of vitamin E acetate contained in phopholipid nanoemulsions was investigated with hamster cheek pouch. Introduction of oils with extremely low water-solubility and low viscosity induced narrow droplet size distribution and smaller mean droplet size of nanoemulsions containing vitamin E acetate, while nanoemulsions of vitamin E acetate alone were unstable. Freeze-fracture electron microscopy revealed that droplet size of nanoemulsions were in the range of 50 ~ 200 nm and their structures were maintained in toothpaste formulation as an oral composition. In vitro and in vivo assessments indicated that nanoemulsions and oral compositions containing the same facilitated the infiltration of vitamin E acetate into oral mucous membrane of hamster cheek pouches.

Keywords:vitamin E acetate;nanoemulsion;oral mucous membrane;infiltration

[References]

Tadros F, Cosmetic Science for the New Century, pp. 442-458, 21st IFSCC, Berlin (2000)
Chung H, Kim TW, Kwon M, Kwon IC, Jeong SY, J. Control. Release, 71, 339 (2001)
Fillery-Travis AJ, Foster LH, Robins MM, Biophys. Chem., 54, 153 (1995)
Jumaa M, Muller BW, Int. J. Pharm., 163, 81 (1998)
Chansiri G, Lyons RT, Patel MV, Hem SL, J. Pharm. Sci., 88, 454 (1999)
Foldvari M, Pharm. Sci. Tech. Today, 3, 417 (2000)
Gershanik T, Benita S, Eur. J. Pharm. Biopharm., 50, 179 (2000)
Hauss DJ, Fogal SE, Ficorilli JV, Price CA, Roy T, Jayaraj AA, Keirns JJ, J. Pharm. Sci., 87, 164 (1998)
Norden TP, Siekmann B, Lundquist S, Malmsten M, Eur. J. Pharm. Sci., 13, 393 (2001)
Fleisher D, Niemiec SM, Oh CK, Hu Z, Ramachandran C, Weiner N, Life Sci., 57, 1293 (1995)
Kim JB, Paik DI, Moon HS, J. Korean Acad. Dental Health, 12, 7 (1988)
Kim YM, Park KI, Choi E, J. Korean Acad. Dental Health, 15, 83 (1991)
Ma DS, Jin BH, Park DY, Kim JB, Paik DI, Moon HS, J. Korean Acad. Dental Health, 18, 557 (1994)
Welin-Berger K, Bergenstahl B, Int. J. Pharm., 200, 249 (2000)
Jumaa M, Mller BW, Int. J. Pharm., 163, 81 (1998)
Asai Y, Watanabe W, Eur. J. Pharm. Biopharm., 48, 77 (1999)

[Referenced By]

[1] Tadros F, Cosmetic Science for the New Century, pp. 442-458, 21st IFSCC, Berlin (2000)

[2] Chung H, Kim TW, Kwon M, Kwon IC, Jeong SY, J. Control. Release, 71, 339 (2001)

[3] Fillery-Travis AJ, Foster LH, Robins MM, Biophys. Chem., 54, 153 (1995)

[4] Jumaa M, Muller BW, Int. J. Pharm., 163, 81 (1998)

[5] Chansiri G, Lyons RT, Patel MV, Hem SL, J. Pharm. Sci., 88, 454 (1999)

[6] Foldvari M, Pharm. Sci. Tech. Today, 3, 417 (2000)

[7] Gershanik T, Benita S, Eur. J. Pharm. Biopharm., 50, 179 (2000)

[8] Hauss DJ, Fogal SE, Ficorilli JV, Price CA, Roy T, Jayaraj AA, Keirns JJ, J. Pharm. Sci., 87, 164 (1998)

[9] Norden TP, Siekmann B, Lundquist S, Malmsten M, Eur. J. Pharm. Sci., 13, 393 (2001)

[10] Fleisher D, Niemiec SM, Oh CK, Hu Z, Ramachandran C, Weiner N, Life Sci., 57, 1293 (1995)

[11] Kim JB, Paik DI, Moon HS, J. Korean Acad. Dental Health, 12, 7 (1988)

[12] Kim YM, Park KI, Choi E, J. Korean Acad. Dental Health, 15, 83 (1991)

[13] Ma DS, Jin BH, Park DY, Kim JB, Paik DI, Moon HS, J. Korean Acad. Dental Health, 18, 557 (1994)

[14] Welin-Berger K, Bergenstahl B, Int. J. Pharm., 200, 249 (2000)

[15] Jumaa M, Mller BW, Int. J. Pharm., 163, 81 (1998)

[16] Asai Y, Watanabe W, Eur. J. Pharm. Biopharm., 48, 77 (1999)