Swelling Properties of poly(AM-co-AA)/Chitosan pH Sensitive Superporous Hydrogels

Kwang-Won Seo; Duk-Joon Kim; Ki-Nam Park

Journal of Industrial and Engineering Chemistry, Vol.10, No.5, 794-800, September, 2004

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Swelling Properties of poly(AM-co-AA)/Chitosan pH Sensitive Superporous Hydrogels

Kwang-Won Seo, Duk-Joon Kim^†, and Ki-Nam Park¹

Department of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea
¹School of Pharmacy, Purdue University, West Lafayette, IN 47907, USA

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Superporous hydrogels (SPHs) of poly(acrylamide-co-acrylic acid) [P(AM-co-AA)]/chitosan and P(AM-co-AA)/glycol chitosan interpenetrating polymer networks (IPNs) were prepared, and their swelling and mechanical properties were investigated. The introduction time of the blowing agent was determined from gelation reaction exotherms. For both SPH systems, equilibrium swelling ratios decreased in distilled water, but increased in simulated gastric fluid, as the chitosan concentration increased. Replacement of glycol chitosan for chitosan led to a significant increase in the swelling rate because of its high water affinity. Equilibrium swelling ratios were mostly governed by the ionic concentration difference between the gel and bulk phases, but the swelling rate depended upon the pore size and structure. The compressive strength of P(AM-co-AA)/chitosan IPN SPHs swollen in water was very weak, but that in simulated gastric fluid was over 60 KPa.

Keywords:superporous hydrogels;swelling;poly(acrylic acid);chitosan

[References]

Kost J, Langer R, Adv. Drug Deliv. Rev., 46, 125 (2001)
Qiu Y, Park K, Adv. Drug Deliv. Rev., 53, 321 (2001)
Hoffman AS, Adv. Drug Deliv. Rev., 54, 3 (2002)
Kim JH, Lee JH, Yoon SW, J. Ind. Eng. Chem., 8(2), 138 (2002)
Kang HS, Kwon SS, Kim BH, Lee BR, Kang KH, Hong JE, Han SH, Chang IS, J. Ind. Eng. Chem., 8(4), 348 (2002)
Kim Y, Kwon I, Jeong S, Polym. Sci. Technol., 6, 544 (1994)
Chen J, Park H, Park K, J. Biomed. Mater. Res., 44, 53 (1999)
Chen J, Park K, Carbohydr. Polym., 41, 259 (2000)
Chen J, Park K, J. Control. Release, 65, 73 (2000)
Gemeinhart RA, Park H, Park K, Polym. Adv. Technol., 11, 617 (2000)
Gemeinhart RA, Park H, Park K, J. Biomed. Mater. Res., 55, 54 (2001)
Chen J, Park K, J. Control. Release, 64, 39 (2000)
Gemeinhart RA, Chen J, Park H, Park K, J. Biomater. Sci.-Polym. Ed., 12, 1371 (2001)
Shimomura T, Namba T, in Superabsorbent Polymers: Science and Technology. ACS Symposium Series # 573, F. L. Buchholz and N. A. Peppas, Eds., American Chemical Society, Washington DC (1994)
Weaver MO, Bagley EB, Fanta GF, Doane WM, US Patent No. 3,981,100 (1976)
Katime I, Novoa R, Apodaca ED, Mendizabal E, Puig J, Polym. Test, 18, 559 (1999)
Liu MZ, Guo TH, J. Appl. Polym. Sci., 82(6), 1515 (2001)
Hirano S, Polym. Int., 48, 732 (1999)
Khalid MN, Agnely F, Yagoubi N, Grossiord JL, Couarraze G, Eur. J. Pharm. Sci., 15, 452 (2002)
Majeti NV, Ravi K, React. Funct. Polym., 46, 1 (2000)
Chellat F, Tabrizian M, Dumitriu S, Chornet E, Rivard C, Yahia L, J. Biomed. Mater. Res., 53, 592 (2000)

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[1] Kost J, Langer R, Adv. Drug Deliv. Rev., 46, 125 (2001)

[2] Qiu Y, Park K, Adv. Drug Deliv. Rev., 53, 321 (2001)

[3] Hoffman AS, Adv. Drug Deliv. Rev., 54, 3 (2002)

[4] Kim JH, Lee JH, Yoon SW, J. Ind. Eng. Chem., 8(2), 138 (2002)

[5] Kang HS, Kwon SS, Kim BH, Lee BR, Kang KH, Hong JE, Han SH, Chang IS, J. Ind. Eng. Chem., 8(4), 348 (2002)

[6] Kim Y, Kwon I, Jeong S, Polym. Sci. Technol., 6, 544 (1994)

[7] Chen J, Park H, Park K, J. Biomed. Mater. Res., 44, 53 (1999)

[8] Chen J, Park K, Carbohydr. Polym., 41, 259 (2000)

[9] Chen J, Park K, J. Control. Release, 65, 73 (2000)

[10] Gemeinhart RA, Park H, Park K, Polym. Adv. Technol., 11, 617 (2000)

[11] Gemeinhart RA, Park H, Park K, J. Biomed. Mater. Res., 55, 54 (2001)

[12] Chen J, Park K, J. Control. Release, 64, 39 (2000)

[13] Gemeinhart RA, Chen J, Park H, Park K, J. Biomater. Sci.-Polym. Ed., 12, 1371 (2001)

[14] Shimomura T, Namba T, in Superabsorbent Polymers: Science and Technology. ACS Symposium Series # 573, F. L. Buchholz and N. A. Peppas, Eds., American Chemical Society, Washington DC (1994)

[15] Weaver MO, Bagley EB, Fanta GF, Doane WM, US Patent No. 3,981,100 (1976)

[16] Katime I, Novoa R, Apodaca ED, Mendizabal E, Puig J, Polym. Test, 18, 559 (1999)

[17] Liu MZ, Guo TH, J. Appl. Polym. Sci., 82(6), 1515 (2001)

[18] Hirano S, Polym. Int., 48, 732 (1999)

[19] Khalid MN, Agnely F, Yagoubi N, Grossiord JL, Couarraze G, Eur. J. Pharm. Sci., 15, 452 (2002)

[20] Majeti NV, Ravi K, React. Funct. Polym., 46, 1 (2000)

[21] Chellat F, Tabrizian M, Dumitriu S, Chornet E, Rivard C, Yahia L, J. Biomed. Mater. Res., 53, 592 (2000)