약물반응 조절에 미치는 탄소나노튜브가 첨가된 하이드로젤의 불소화 영향

김지현; 배태성; 이영석; Ji-Hyun Kim; Tae-Sung Bae; Young-Seak Lee

Polymer(Korea), Vol.39, No.6, 925-933, November, 2015

DOI10.7317/pk.2015.39.6.925 Export Citation

약물반응 조절에 미치는 탄소나노튜브가 첨가된 하이드로젤의 불소화 영향

Effect of Fluorination of Hydrogels Containing CNTs on Controlled Drug Reactivity

김지현, 배태성¹, 이영석 ^†

충남대학교 바이오응용화학과
¹한국기초과학지원연구원

Ji-Hyun Kim, Tae-Sung Bae¹, and Young-Seak Lee^†

Department of Applied Chemistry and Biological Engineering, Chungnam National University, Daejeon 305-764, Korea
¹Korea Basic Science Institute (KBSI), Jeonju Center, Jeonju 561-756, Korea

E-mail:

초록

탄소나노튜브(carbon nanotubes, CNTs)가 첨가된 하이드로젤의 약물방출속도를 용이하게 조절하기 위하여 소수성 관능기를 가지는 불소화 처리를 실시하였다. 이때 약물방출속도를 조사하기 위한 모델 약물로서 지용성물질인 비타민 D3를 사용하였다. 하이드로젤의 불소화 반응이 CNT 첨가로 인하여 훨씬 용이하였으며, 이는 CNTs가 첨가되지 않은 하이드로젤과 비교하여 반응성이 1.6배 높았다. 비타민 D3가 첨가된 하이드로젤의 불소화 반응은 약물방출조절 효과를 크게 증가시켰다. 또한 CNTs가 첨가된 하이드로젤 표면에 증가된 불소함량은 초기약물방출속도의 조절에 영향을 주었다. 하이드로젤 표면 불소화가 증가할수록 비타민 D3와의 표면 반응으로 인하여 약물방출효율이 크게 증가하였다.

Hydrogels containing carbon nanotubes (CNTs) were fluorinated with hydrophobic functional groups to control the drug releasing rate. Vitamin D3, a fat-soluble material, was used as the model drug to investigate the drug deliver rate. The hydrogel containing CNTs was fluorinated well due to the CNTs, and fluorinated hydrogels had 1.6 times greater reactivity than those of the hydrogels lacking CNTs. The fluorination of hydrogels containing vitamin D3 substantially increased the effect of drug releasing efficiency. Additionally, the increased fluorine contents of hydrogels containing CNTs had affected on controlling the initial drug releasing rate. The drug releasing efficiency was remarkably increased by more fluorination due to the reactivity of vitamin D3 with fluorinated hydrogel surface.

Keywords:hydrogels;CNTs;fluorination;functional groups;vitamin D3;drug releasing rate

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[9] Peppas NA, Bures P, Leobandung W, Ichikawa H, Eur. J. Pharm. Biopharm., 50, 27 (2000)

[10] Ashara KC, Paun JS, Soniwala MM, Chavada JR, Mori NM, Asian Pac. J. Trop. Dis., 4, S27 (2014)

[11] Im JS, Lee SK, Bai BC, Lee YS, J. Ind. Eng. Chem., 18(1), 325 (2012)

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[14] Rub MA, Azum N, Kumar D, Khan F, Asiri AM, J. Ind. Eng. Chem., 21, 1119 (2015)

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[21] Nandakumar A, Birgani ZT, Santos D, Mentink A, Auffermann N, van derWerf K, Bennink M, Moroni L, van Blitterswijk C, Habibovic P, Biofabrication, 5, 015006 (2013)

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[26] Pandey PK, Smitha P, Gajbhiye NS, J. Polym. Res., 15, 397 (2008)

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[28] Yudianti R, Onggo H, Surirman, Saito Y, Iwata T, Azuma J, Open Mater. Sci. J., 5, 242 (2011)

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