화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Polymer(Korea), Vol.39, No.6, 831-836, November, 2015
DOI10.7317/pk.2015.39.6.831  Export Citation
나노의학용 생분해성 나노입자
Biodegradable Nanoparticles for Nanomedicines
김민섭, 박상준, 구본강, 김천호†
  • 한국원자력의학원 방사선의학연구소
Min Sup Kim, Sang Jun Park, Bon Kang Gu, and Chun-Ho Kim†
  • Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul 139-240, Korea
E-mail:
초록
최근 들어 나노의학에 사용되는 생분해성 나노입자는 치료용 제제를 효과적으로 전달하기 위한 전달체로 큰 주목을 받고 있다. 특히, 생분해성 고분자를 기반으로 제조한 나노입자는 친수성 담지 약물의 안정성 유지한 상태로 약물을 전달하고자 하는 부위로 찾아가 약물의 서방형 방출거동을 통해 약물의 효과를 극대화하며 약물에 의한 부작용을 최소화해야 할 것이다. 따라서 본 고에서는 나노의학에 응용이 가능한 생분해성 물질인 단백질과 다당류 등과 같은 천연고분자에 대한 소개와 이를 이용한 나노입자의 제조 방법에 대해 소개하였다.
Biodegradable polymeric nanoparticles (NPs) have shown significant therapeutic potential as nanomedicines for delivery of pharmaceutical agents. NPs made of biodegradable polymers can efficiently deliver drugs for sustained, controlled and targeted release, enhancing the stability of hydrophilic bioactive molecules, thereby improving their therapeutic efficacy while reducing their side effects. This paper reviews candidate biodegradable materials for NPs, including proteins and polysaccharides, and their methods of NP fabrication for nanomedicines.
Keywords:biodegradable nanoparticles;polymeric nanoparticles;nanomedicine;drug delivery;tissue engineering
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