화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.104, 345-355, December, 2021
DOI10.1016/j.jiec.2021.08.035  Export Citation
Fabrication of copper ions-substituted hydroxyapatite/polydopamine nanocomposites with high antibacterial and angiogenesis effects for promoting infected wound healing
Bailong Tao1, 2, Chuanchuan Lin2, Ai Guo3, Yonglin Yu4, Xian Qin5, Kai Li6, Hongchuan Tian7, Weiwei Yi8, Dengliang Lei9, and Lixue Chen1, †
  • 1Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • 2Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China
  • 3Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • 4Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China
  • 5Department of Reproductive Endocrinology, Chongqing Health Center for Women and Children, Chongqing 401147, China
  • 6Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
  • 7Department of Orthopedics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • 8Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, China
  • 9Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Infected wound healing remains a critical threat, which frequently delays the healing process and even leads to severe life-threatening complications. Herein, we reported an effective anti-infection approach, which was based on copper ions-releasing hydroxyapatite/polydopamine (HA-Cu/PDA) nanocomposites with photothermal effect. The HA-Cu/PDA nanocomposites was fabricated through a co-precipitation reaction between polydopamine (PDA)-coated hydroxyapatite nanoparticles (HA)-loaded Cu2+ (HA-Cu). Through a synergistic effect of released Cu2+ and photothermal efficiency of PDA coating, and the HACu/ PDA nanocomposites exhibited extraordinary antibacterial capacities against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The nanocomposites presented good biocompatibility for mouse embryonic fibroblast (NIH-3T3) cells and promoted NIH3T3 cells to migrate toward wound sites. Additionally, this nanocomposite could stimulate the tissue remodeling-related gene expression to induce the blood vessels formation, granulation tissues and collagen deposition, and eventually enhance wound healing. In vivo study further verified that HA-Cu/PDA nanocomposites with NIR irradiation could significantly improve bacterial infected wound healing through the prominent antibacterial property, reduced inflammatory response, the formation of granulation tissue, collagen deposition, and angiogenesis ability. Thus, this study develops a versatile strategy for a broad range of wound healing and skin reconstruction caused by bacterial infection.
Keywords:Hydroxyapatite;Antibacterial property;Photothermal therapy;Angiogenesis;Wound healing
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